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Harutyunyan G, Hauer L, Dünser MW, et al. Risk Factors for Intensive Care Unit Admission in Patients with Autoimmune Encephalitis. Front Immunol. 2017;8:835doi: 10.3389/fimmu.2017.00835.
Harutyunyan, G., Hauer, L., Dünser, M. W., Moser, T., Pikija, S., Leitinger, M., Novak, H. F., Aichhorn, W., Trinka, E., & Sellner, J. (2017). Risk Factors for Intensive Care Unit Admission in Patients with Autoimmune Encephalitis. Frontiers in immunology, 8835. https://doi.org/10.3389/fimmu.2017.00835
Harutyunyan, Gayane, et al. "Risk Factors for Intensive Care Unit Admission in Patients with Autoimmune Encephalitis." Frontiers in immunology vol. 8 (2017): 835. doi: https://doi.org/10.3389/fimmu.2017.00835
Harutyunyan G, Hauer L, Dünser MW, Moser T, Pikija S, Leitinger M, Novak HF, Aichhorn W, Trinka E, Sellner J. Risk Factors for Intensive Care Unit Admission in Patients with Autoimmune Encephalitis. Front Immunol. 2017 Jul 28;8:835. doi: 10.3389/fimmu.2017.00835. eCollection 2017. PMID: 28804482; PMCID: PMC5532517.
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Front Immunol. 2017 Jul 28;8:835. doi: 10.3389/fimmu.2017.00835. eCollection 2017.

Risk Factors for Intensive Care Unit Admission in Patients with Autoimmune Encephalitis.

Frontiers in immunology

Gayane Harutyunyan, Larissa Hauer, Martin W Dünser, Tobias Moser, Slaven Pikija, Markus Leitinger, Helmut F Novak, Wolfgang Aichhorn, Eugen Trinka, Johann Sellner

Affiliations

  1. Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria.
  2. Department of Psychiatry and Psychotherapy, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria.
  3. Department of Critical Care, University College of London Hospital, London, United Kingdom.
  4. Department of Neurology, Klinikum rechts der Isar, Technische Universität München, München, Germany.

PMID: 28804482 PMCID: PMC5532517 DOI: 10.3389/fimmu.2017.00835

Abstract

BACKGROUND: Prevention and early recognition of critical illness in patients with autoimmune encephalitis (AE) is essential to achieve better outcome.

AIM OF THE STUDY: To evaluate risk factors for intensive care unit (ICU) admission and its prognostic impact in patients with AE.

PATIENTS AND METHODS: A reclassification of patients hospitalized between 2011 and 2016 revealed 17 "definite" and 15 "probable" AE cases. Thirteen patients (41%) developed critical illness and required ICU admission. The underlying conditions were intractable seizures or status epilepticus (54%), altered mental state (39%), and respiratory failure (8%).

RESULTS: ICU admission was associated with longer time from first symptoms to hospitalization (

CONCLUSION: We confirmed the need for ICU care in a subgroup of patients and the prevailing objective is improved seizure control, and definite diagnosis of AE and anemia were identified as risk factors for development of critical illness. However, prognosis was not affected by ICU admission.

Keywords: autoimmune encephalitis; critical care; humoral immunity; neurodegeneration; prognosis; seizures

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