Display options
Cite
Evers ES, Walavalkar V, Pujar S, et al. Does heart-type fatty acid-binding protein predict clinical outcomes after pediatric cardiac surgery?. Ann Pediatr Cardiol. 2017;10(3):245-247doi: 10.4103/apc.APC_33_17.
Evers, E. S., Walavalkar, V., Pujar, S., Balasubramanian, L., Prinzen, F. W., Delhaas, T., Vanagt, W. Y., & Maiya, S. (2017). Does heart-type fatty acid-binding protein predict clinical outcomes after pediatric cardiac surgery?. Annals of pediatric cardiology, 10(3), 245-247. https://doi.org/10.4103/apc.APC_33_17
Evers, Egmond S, et al. "Does heart-type fatty acid-binding protein predict clinical outcomes after pediatric cardiac surgery?." Annals of pediatric cardiology vol. 10,3 (2017): 245-247. doi: https://doi.org/10.4103/apc.APC_33_17
Evers ES, Walavalkar V, Pujar S, Balasubramanian L, Prinzen FW, Delhaas T, Vanagt WY, Maiya S. Does heart-type fatty acid-binding protein predict clinical outcomes after pediatric cardiac surgery?. Ann Pediatr Cardiol. 2017 Sep-Dec;10(3):245-247. doi: 10.4103/apc.APC_33_17. PMID: 28928610; PMCID: PMC5594935.
Copy Download .nbib Format: NLM
Share it on

Ann Pediatr Cardiol. 2017 Sep-Dec;10(3):245-247. doi: 10.4103/apc.APC_33_17.

Does heart-type fatty acid-binding protein predict clinical outcomes after pediatric cardiac surgery?.

Annals of pediatric cardiology

Egmond S Evers, Varsha Walavalkar, Suresh Pujar, Latha Balasubramanian, Frits W Prinzen, Tammo Delhaas, Ward Y Vanagt, Shreesha Maiya

Affiliations

  1. Department of Physiology and Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
  2. Department of Pedicatric Cardiology, Narayana Institute of Cardiac Sciences, Bengaluru, Karnataka, India.

PMID: 28928610 PMCID: PMC5594935 DOI: 10.4103/apc.APC_33_17

Abstract

INTRODUCTION: The early identification of vulnerable pediatric cardiac surgery patients can help clinicians provide them with timely support. Heart-type fatty acid-binding protein. (H-FABP) is an early biomarker of myocardial injury in acute myocardial infarction in adults. In this study, we evaluated the correlations between postoperative H-FABP, creatine kinase-myocardial band (CK-MB), troponin-I, total bypass time, and clinical outcomes.

METHODS: In 32 pediatric patients that underwent ventricular septal defect. closure we measured H-FABP, troponin-I and CK-MB preoperatively and 1, 3, and 6 h after aortic declamping. Spearman's Rho correlations were calculated between laboratory and clinical parameters including inotropic support duration, aortic cross-clamp time, total bypass time, ventilation-weaning-time, and total Intensive Care Unit stay.

RESULTS: H-FABP, CK-MB, troponin-I, and total bypass time have a similarly weak to moderate correlation with clinical outcome measures.

CONCLUSIONS: The predictive value of H-FABP for clinical outcome is not stronger than that of CK-MB, Troponin-I, or bypass times.

Keywords: Bypass time; heart-type fatty acid-binding protein; pediatric cardiac surgery

Conflict of interest statement

There are no conflicts of interest.

References

  1. Ann Thorac Surg. 2016 Mar;101(3):850-62 - PubMed
  2. Clin Chem Lab Med. 2000 Mar;38(3):231-8 - PubMed
  3. J Thorac Cardiovasc Surg. 2005 Jan;129(1):192-8 - PubMed
  4. J Thorac Cardiovasc Surg. 2004 Jun;127(6):1697-702 - PubMed
  5. Eur J Cardiothorac Surg. 2016 May;49(5):1403-10 - PubMed
  6. Clin Chim Acta. 2005 Feb;352(1-2):15-35 - PubMed

Publication Types