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Kidney Int Rep. 2017 May;2(3):390-399. doi: 10.1016/j.ekir.2017.01.002. Epub 2017 Jan 10.

Associations of Protein-Energy Wasting Syndrome Criteria With Body Composition and Mortality in the General and Moderate Chronic Kidney Disease Populations in the United States.

Kidney international reports

Srinivasan Beddhu, Xiaorui Chen, Guo Wei, Dominic Raj, Kalani L Raphael, Robert Boucher, Michel B Chonchol, Maureen A Murtaugh, Tom Greene

Affiliations

  1. Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, UT.
  2. Department of Medicine, University of Utah School of Medicine, Salt Lake City UT.
  3. Department of Medicine, George Washington School of Medicine, Washington, DC.
  4. Department of Medicine, University of Colorado School of Medicine, Denver, CO.
  5. Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City UT.

PMID: 28840197 PMCID: PMC5563827 DOI: 10.1016/j.ekir.2017.01.002

Abstract

INTRODUCTION: It is unknown whether the criteria used to define Protein-energy wasting (PEW) syndrome in dialysis patients reflect protein or energy wasting in the general and moderate CKD populations.

METHODS: In 11,834 participants in the 1999-2004 National Health and Nutrition Examination Survey, individual PEW syndrome criteria and the number of PEW syndrome categories were related to lean body and fat masses (measured by dual-energy absorptiometry) using linear regression in the entire cohort and CKD sub-population.

RESULTS: Serum chemistry, body mass and muscle mass PEW criteria tended to be associated with lower lean body and fat masses, but the low dietary protein and energy intake criteria were associated with significantly

CONCLUSION: Hence, a definition of PEW syndrome without dietary variables has face validity and reflects protein or energy wasting.

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