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Newby BN, Mathews CE. Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment. Front Endocrinol (Lausanne). 2017;8:232doi: 10.3389/fendo.2017.00232.
Newby, B. N., & Mathews, C. E. (2017). Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment. Frontiers in endocrinology, 8232. https://doi.org/10.3389/fendo.2017.00232
Newby, Brittney N, and Mathews, Clayton E. "Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment." Frontiers in endocrinology vol. 8 (2017): 232. doi: https://doi.org/10.3389/fendo.2017.00232
Newby BN, Mathews CE. Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment. Front Endocrinol (Lausanne). 2017 Sep 14;8:232. doi: 10.3389/fendo.2017.00232. eCollection 2017. PMID: 28959234; PMCID: PMC5604085.
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Front Endocrinol (Lausanne). 2017 Sep 14;8:232. doi: 10.3389/fendo.2017.00232. eCollection 2017.

Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment.

Frontiers in endocrinology

Brittney N Newby, Clayton E Mathews

Affiliations

  1. Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, United States.

PMID: 28959234 PMCID: PMC5604085 DOI: 10.3389/fendo.2017.00232

Abstract

A detailed understanding of the molecular pathways and cellular interactions that result in islet beta cell (β cell) destruction is essential for the development and implementation of effective therapies for prevention or reversal of type 1 diabetes (T1D). However, events that define the pathogenesis of human T1D have remained elusive. This gap in our knowledge results from the complex interaction between genetics, the immune system, and environmental factors that precipitate T1D in humans. A link between genetics, the immune system, and environmental factors are type 1 interferons (T1-IFNs). These cytokines are well known for inducing antiviral factors that limit infection by regulating innate and adaptive immune responses. Further, several T1D genetic risk loci are within genes that link innate and adaptive immune cell responses to T1-IFN. An additional clue that links T1-IFN to T1D is that these cytokines are a known constituent of the autoinflammatory milieu within the pancreas of patients with T1D. The presence of IFNα/β is correlated with characteristic MHC class I (MHC-I) hyperexpression found in the islets of patients with T1D, suggesting that T1-IFNs modulate the cross-talk between autoreactive cytotoxic CD8

Keywords: CD8+ T cell; beta cells; humans; type 1 diabetes; type 1 interferons

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