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Beilstein J Nanotechnol. 2017 Jul 18;8:1484-1493. doi: 10.3762/bjnano.8.148. eCollection 2017.

Calcium fluoride based multifunctional nanoparticles for multimodal imaging.

Beilstein journal of nanotechnology

Marion Straßer, Joachim H X Schrauth, Sofia Dembski, Daniel Haddad, Bernd Ahrens, Stefan Schweizer, Bastian Christ, Alevtina Cubukova, Marco Metzger, Heike Walles, Peter M Jakob, Gerhard Sextl

Affiliations

  1. Fraunhofer Institute for Silicate Research ISC, Neunerplatz 2, 97082 Wuerzburg, Germany.
  2. Department of Chemical Technology of Materials Synthesis, University of Wuerzburg, Roentgenring 11, 97070 Wuerzburg, Germany.
  3. MRB Research Center for Magnetic Resonance Bavaria, Am Hubland, 97074 Wuerzburg, Germany.
  4. Department of Experimental Physics 5 (Biophysics), University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany.
  5. Translational Center Wuerzburg "Regenerative Therapies for Oncology and Musculosceletal Diseases", Branch of Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, 97070 Wuerzburg, Germany.
  6. University Hospital Wuerzburg, Chair Tissue Engineering and Regenerative Medicine, Roentgenring 11, 97070 Wuerzburg, Germany.
  7. Magnetic Resonance and X-ray Imaging Department of Fraunhofer Development Center X-ray Technology EZRT, a division of Fraunhofer Institute for Integrated Circuits IIS, Am Hubland, 97074 Wuerzburg, Germany.
  8. South Westphalia University of Applied Sciences, Luebecker Ring 2, 59494 Soest, Germany.
  9. Fraunhofer Application Center for Inorganic Phosphors, Branch Lab of Fraunhofer Institute for Microstructure of Materials and Systems IMWS, Luebecker Ring 2, 59494 Soest, Germany.

PMID: 28900602 PMCID: PMC5530611 DOI: 10.3762/bjnano.8.148

Abstract

New multifunctional nanoparticles (NPs) that can be used as contrast agents (CA) in different imaging techniques, such as photoluminescence (PL) microscopy and magnetic resonance imaging (MRI), open new possibilities for medical imaging, e.g., in the fields of diagnostics or tissue characterization in regenerative medicine. The focus of this study is on the synthesis and characterization of CaF

Keywords: calcium fluoride nanoparticles; magnetic resonance imaging (MRI); multifunctional nanoparticles; multimodal imaging; photoluminescence

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