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El-Newary SA, Ibrahim AY, Asker MS, et al. Production, characterization and biological activities of acidic exopolysaccharide from marine Bacillus amyloliquefaciens 3MS 2017. Asian Pac J Trop Med. 2017;10(7):652-662doi: 10.1016/j.apjtm.2017.07.005.
El-Newary, S. A., Ibrahim, A. Y., Asker, M. S., Mahmoud, M. G., & El Awady, M. E. (2017). Production, characterization and biological activities of acidic exopolysaccharide from marine Bacillus amyloliquefaciens 3MS 2017. Asian Pacific journal of tropical medicine, 10(7), 652-662. https://doi.org/10.1016/j.apjtm.2017.07.005
El-Newary, Samah A, et al. "Production, characterization and biological activities of acidic exopolysaccharide from marine Bacillus amyloliquefaciens 3MS 2017." Asian Pacific journal of tropical medicine vol. 10,7 (2017): 652-662. doi: https://doi.org/10.1016/j.apjtm.2017.07.005
El-Newary SA, Ibrahim AY, Asker MS, Mahmoud MG, El Awady ME. Production, characterization and biological activities of acidic exopolysaccharide from marine Bacillus amyloliquefaciens 3MS 2017. Asian Pac J Trop Med. 2017 Jul;10(7):652-662. doi: 10.1016/j.apjtm.2017.07.005. Epub 2017 Jul 28. PMID: 28870341.
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Asian Pac J Trop Med. 2017 Jul;10(7):652-662. doi: 10.1016/j.apjtm.2017.07.005. Epub 2017 Jul 28.

Production, characterization and biological activities of acidic exopolysaccharide from marine Bacillus amyloliquefaciens 3MS 2017.

Asian Pacific journal of tropical medicine

Samah A El-Newary, Abeer Y Ibrahim, Mohsen S Asker, Manal G Mahmoud, Mohamed E El Awady

Affiliations

  1. Department of Medicinal and Aromatic Plants Research, National Research Centre, Dokki, Cairo, Egypt. Electronic address: [email protected].
  2. Department of Medicinal and Aromatic Plants Research, National Research Centre, Dokki, Cairo, Egypt.
  3. Microbial Biotechnology Department, National Research Centre, Dokki, Cairo, Egypt.

PMID: 28870341 DOI: 10.1016/j.apjtm.2017.07.005

Abstract

OBJECTIVE: To evaluate in-vitro antioxidant, anti-inflammatory and antitumor abilities against human breast adenocarcinoma (MCF7) and human prostate cancer (PC3) as well as the suppressor effect of bacterial exopolysaccharide (BAEPS) on Ehrlich ascites carcinoma (EAC).

METHODS: In-vitro antioxidants characters of BAEPS were determined using various methods, while anti-inflammatory activity was estimated against cyclooxygenase (COX-1 and COX-2). In-vitro study, anticancer against MCF7 and PC3 were assessed by the mitochondrial dependent reduction of yellow MTT. In in-vivo study against EAC progression, mice were inoculated with EAC cells and then were orally administered BAEPS at 200 mg/kg after 24 h (equals to 0.10 of determined LD

RESULTS: BAEPS was acidic exopolysaccharide contained uronic acid (12.3%) and sulfate (22.8%) with constitution of glucose, galactose and glucuronic acid in a molar ratio 1.6:1.0:0.9, respectively, with a molecular mass of 3.76 × 10

CONCLUSIONS: BAEPS has anti-tumor activity with a good margin of safety. The anti-tumor activity of BAEPS may be due to its content from sulfated groups and uronic acids and they have antioxidant and anti-inflammatory properties.

Copyright © 2017 Hainan Medical University. Production and hosting by Elsevier B.V. All rights reserved.

Keywords: Anti-inflammatory; Anti-tumor; Antioxidant; Bacillus amyloliquefaciens; Ehrlich ascites carcinoma; Exopolysaccharide

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