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Doerstling SS, O'Flanagan CH, Hursting SD. Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Front Oncol. 2017;7:216doi: 10.3389/fonc.2017.00216.
Doerstling, S. S., O'Flanagan, C. H., & Hursting, S. D. (2017). Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Frontiers in oncology, 7216. https://doi.org/10.3389/fonc.2017.00216
Doerstling, Steven S, et al. "Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors." Frontiers in oncology vol. 7 (2017): 216. doi: https://doi.org/10.3389/fonc.2017.00216
Doerstling SS, O'Flanagan CH, Hursting SD. Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Front Oncol. 2017 Sep 14;7:216. doi: 10.3389/fonc.2017.00216. eCollection 2017. PMID: 28959684; PMCID: PMC5604081.
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Front Oncol. 2017 Sep 14;7:216. doi: 10.3389/fonc.2017.00216. eCollection 2017.

Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors.

Frontiers in oncology

Steven S Doerstling, Ciara H O'Flanagan, Stephen D Hursting

Affiliations

  1. Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
  2. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
  3. University of North Carolina Nutrition Research Institute, Kannapolis, NC, United States.

PMID: 28959684 PMCID: PMC5604081 DOI: 10.3389/fonc.2017.00216

Abstract

Obesity is associated with increased risk and poor prognosis of many types of cancers. Several obesity-related host factors involved in systemic metabolism can influence tumor initiation, progression, and/or response to therapy, and these have been implicated as key contributors to the complex effects of obesity on cancer incidence and outcomes. Such host factors include systemic metabolic regulators including insulin, insulin-like growth factor 1, adipokines, inflammation-related molecules, and steroid hormones, as well as the cellular and structural components of the tumor microenvironment, particularly adipose tissue. These secreted and structural host factors are extrinsic to, and interact with, the intrinsic metabolic characteristics of cancer cells to influence their growth and spread. This review will focus on the interplay of these tumor cell-intrinsic and extrinsic factors in the context of energy balance, with the objective of identifying new intervention targets for preventing obesity-associated cancer.

Keywords: autophagy; calorie restriction; cancer; cancer metabolism; growth factors; inflammation; obesity

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