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Front Physiol. 2017 Sep 06;8:673. doi: 10.3389/fphys.2017.00673. eCollection 2017.

Is Increased Intracellular Calcium in Red Blood Cells a Common Component in the Molecular Mechanism Causing Anemia?.

Frontiers in physiology

Laura Hertz, Rick Huisjes, Esther Llaudet-Planas, Polina Petkova-Kirova, Asya Makhro, Jens G Danielczok, Stephane Egee, Maria Del Mar Mañú-Pereira, Richard van Wijk, Joan-Lluis Vives Corrons, Anna Bogdanova, Lars Kaestner

Affiliations

  1. Research Centre for Molecular Imaging and Screening, Medical School, Saarland UniversityHomburg, Germany.
  2. Department of Clinical Chemistry and Haematology, University Medical Center UtrechtUtrecht, Netherlands.
  3. Red Blood Cell Defects and Hematopoietic Disorders Unit, Josep Carreras Leukaemia Research InstituteBarcelona, Spain.
  4. Red Blood Cell Research Group, Institute of Veterinary Physiology, Vetsuisse Faculty and the Zurich Center for Integrative Human Physiology (ZIHP), University of ZurichZurich, Switzerland.
  5. Centre National de la Recherche Scientifique, UMR 8227 Comparative Erythrocyte's PhysiologyRoscoff, France.
  6. Université Pierre et Marie Curie, Sorbonne UniversitésRoscoff, France.
  7. Laboratoire d'Excellence GR-ExRoscoff, France.
  8. Theoretical Medicine and Biosciences, Saarland UniversityHomburg, Germany.
  9. Experimental Physics, Saarland UniversitySaarbruecken, Germany.

PMID: 28932200 PMCID: PMC5592231 DOI: 10.3389/fphys.2017.00673

Abstract

For many hereditary disorders, although the underlying genetic mutation may be known, the molecular mechanism leading to hemolytic anemia is still unclear and needs further investigation. Previous studies revealed an increased intracellular Ca

Keywords: calcium homeostasis; channelopathies; erythrocyte; live cell imaging; rare anemia; spherocytosis; xerocytosis

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