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Alese MO, Adewole SO, Akinwunmi KF, et al. Aspirin-Induced Gastric Lesions Alters EGFR and PECAM-1 Immunoreactivity in Wistar Rats: Modulatory Action of Flavonoid Fraction of . Open Access Maced J Med Sci. 2017;5(5):569-577doi: 10.3889/oamjms.2017.058.
Alese, M. O., Adewole, S. O., Akinwunmi, K. F., Omonisi, A. E., & Alese, O. O. (2017). Aspirin-Induced Gastric Lesions Alters EGFR and PECAM-1 Immunoreactivity in Wistar Rats: Modulatory Action of Flavonoid Fraction of . Open access Macedonian journal of medical sciences, 5(5), 569-577. https://doi.org/10.3889/oamjms.2017.058
Alese, Margaret Olutayo, et al. "Aspirin-Induced Gastric Lesions Alters EGFR and PECAM-1 Immunoreactivity in Wistar Rats: Modulatory Action of Flavonoid Fraction of ." Open access Macedonian journal of medical sciences vol. 5,5 (2017): 569-577. doi: https://doi.org/10.3889/oamjms.2017.058
Alese MO, Adewole SO, Akinwunmi KF, Omonisi AE, Alese OO. Aspirin-Induced Gastric Lesions Alters EGFR and PECAM-1 Immunoreactivity in Wistar Rats: Modulatory Action of Flavonoid Fraction of . Open Access Maced J Med Sci. 2017 Jul 26;5(5):569-577. doi: 10.3889/oamjms.2017.058. eCollection 2017 Aug 15. PMID: 28932294; PMCID: PMC5591583.
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Open Access Maced J Med Sci. 2017 Jul 26;5(5):569-577. doi: 10.3889/oamjms.2017.058. eCollection 2017 Aug 15.

Aspirin-Induced Gastric Lesions Alters EGFR and PECAM-1 Immunoreactivity in Wistar Rats: Modulatory Action of Flavonoid Fraction of .

Open access Macedonian journal of medical sciences

Margaret Olutayo Alese, Stephen Olarinde Adewole, Kemi Feyisayo Akinwunmi, Abidemi Emmanuel Omonisi, Oluwole Ojo Alese

Affiliations

  1. Department of Anatomy, College of Medicine, Ekiti State University, Ado Ekiti, Nigeria.
  2. Department of Anatomy, College of Health Sciences, Obafemi Awolowo University, Ile Ife, Nigeria.
  3. Department of Biochemistry, Faculty of Science, Obafemi Awolowo University, Ile Ife, Nigeria.
  4. Department of Anatomic Pathology, College of Medicine, Ekiti State University, Ado Ekiti, Nigeria.
  5. Department of Physiology, College of Medicine, Ekiti State University, Ado Ekiti, Nigeria.

PMID: 28932294 PMCID: PMC5591583 DOI: 10.3889/oamjms.2017.058

Abstract

AIM: In this study, Epithelial Growth Factor Receptor and Platelet Endothelial Cell Adhesion Molecule-1 were localised to investigate the healing effects of a flavonoid-rich fraction of

MATERIALS AND METHODS: Mature, unripe fruits of

RESULTS: There was a significant difference in the ulcer index in the corpus of control and treated rats throughout the experimental period (p = 0.0001). H&E stained sections showed a gradual restoration of the epithelial lining in the treated groups. Immunohistochemical examination showed that

CONCLUSION: The efficacy of

Keywords: Aspirin; EGFR; Gastric lesions; Musa paradisiaca; PECAM-1

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