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Laake K, Seljeflot I, Schmidt EB, et al. Galectin-3, a marker of cardiac remodeling, is inversely related to serum levels of marine omega-3 fatty acids. A cross-sectional study. JRSM Cardiovasc Dis. 2017;6:2048004017729984doi: 10.1177/2048004017729984.
Laake, K., Seljeflot, I., Schmidt, E. B., Myhre, P., Tveit, A., Norseth, J., Arnesen, H., & Solheim, S. (2017). Galectin-3, a marker of cardiac remodeling, is inversely related to serum levels of marine omega-3 fatty acids. A cross-sectional study. JRSM cardiovascular disease, 62048004017729984. https://doi.org/10.1177/2048004017729984
Laake, K, et al. "Galectin-3, a marker of cardiac remodeling, is inversely related to serum levels of marine omega-3 fatty acids. A cross-sectional study." JRSM cardiovascular disease vol. 6 (2017): 2048004017729984. doi: https://doi.org/10.1177/2048004017729984
Laake K, Seljeflot I, Schmidt EB, Myhre P, Tveit A, Norseth J, Arnesen H, Solheim S. Galectin-3, a marker of cardiac remodeling, is inversely related to serum levels of marine omega-3 fatty acids. A cross-sectional study. JRSM Cardiovasc Dis. 2017 Sep 12;6:2048004017729984. doi: 10.1177/2048004017729984. eCollection 2017. PMID: 28932392; PMCID: PMC5600299.
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JRSM Cardiovasc Dis. 2017 Sep 12;6:2048004017729984. doi: 10.1177/2048004017729984. eCollection 2017.

Galectin-3, a marker of cardiac remodeling, is inversely related to serum levels of marine omega-3 fatty acids. A cross-sectional study.

JRSM cardiovascular disease

K Laake, I Seljeflot, E B Schmidt, P Myhre, A Tveit, J Norseth, H Arnesen, S Solheim

Affiliations

  1. Oslo University Hospital, Ullevål, Norway.
  2. Faculty of Medicine, University of Oslo, Norway.
  3. Center for Heart Failure Research, University of Oslo, Norway.
  4. Aalborg University Hospital, Aalborg, Denmark.
  5. Akershus University Hospital, Lørenskog, Norway.
  6. Vestre Viken Hospital Trust, Bærum Hospital, Rud, Norway.

PMID: 28932392 PMCID: PMC5600299 DOI: 10.1177/2048004017729984

Abstract

OBJECTIVE: Marine polyunsaturated n-3 fatty acids (n-3 PUFA) may have cardioprotective effects and beneficial influence on the fibrotic process. We evaluated the associations between serum marine n-3 PUFA and selected biomarkers of fibrosis and cardiac remodeling in elderly patients with acute myocardial infarction.

SETTING: From the ongoing OMega-3 fatty acids in Elderly patients with Myocardial Infarction (OMEMI) trial, 299 patients were investigated. Soluble ST2 (sST2), Galectin-3 (Gal-3) and the serum content of major marine n-3 and n-6 PUFA were analyzed 2-8 weeks after the index acute myocardial infarction.

RESULTS: Gal-3 was inversely correlated to eicosapentaenoic acid (r = -.120,

CONCLUSIONS: The associations between the marine n-3 PUFA and levels of Gal-3 indicate beneficial effects of n-3 PUFA on cardiac remodeling in an elderly population with acute myocardial infarction.

Keywords: Elderly; acute myocardial infarction; cardiac remodeling; heart failure; marine n-3 fatty acids

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