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Urol Case Rep. 2017 Sep 08;15:11-13. doi: 10.1016/j.eucr.2017.08.001. eCollection 2017 Nov.

Successful Treatment with Paclitaxel, Carboplatin, and Gemcitabine as Second-line Chemotherapy for Recurrent Urothelial Carcinoma of the Bladder with Glandular Differentiation After Radical Cystectomy: A Case Report.

Urology case reports

Hiroki Fukuhara, Hiroshi Kakizaki, Hisashi Kaneko, Takuya Yamanobe, Masaki Ushijima, Yuya Kuboki, Norihiko Tsuchiya

Affiliations

  1. Department of Urology, Yamagata University Faculty of Medicine, 2-2-2 Iida-nishi, Yamagata City, Yamagata Prefecture, 998-9585, Japan.
  2. Department of Urology, Nihonkai General Hospital, 30 Akiho-cho, Sakata City, Yamagata Prefecture, 998-8501, Japan.

PMID: 28932689 PMCID: PMC5595231 DOI: 10.1016/j.eucr.2017.08.001

Abstract

Urothelial carcinoma of the bladder (UCB) with glandular differentiation is a histological variant (HV) that is more likely to have positive extravesical tumors or nodes than those in pure UCB. Cisplatin-based neoadjuvant chemotherapy (NAC) prior to radical cystectomy (RC) is more effective for pure UCB; however, few reports are available on second-line chemotherapy for recurrence of UCB with HV. Here we report a 65-year-old Japanese male diagnosed with local recurrence UCB with HV after NAC + RC who safely achieved complete response with paclitaxel, carboplatin, and gemcitabine combination chemotherapy.

Keywords: Bladder cancer; Histological variant; Second-line chemotherapy; Urothelial carcinoma

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