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Rona GB, Almeida DSG, Pinheiro AS, et al. The PWWP domain of the human oncogene WHSC1L1/NSD3 induces a metabolic shift toward fermentation. Oncotarget. 2016;8(33):54068-54081doi: 10.18632/oncotarget.11253.
Rona, G. B., Almeida, D. S. G., Pinheiro, A. S., & Eleutherio, E. C. A. (2017). The PWWP domain of the human oncogene WHSC1L1/NSD3 induces a metabolic shift toward fermentation. Oncotarget, 8(33), 54068-54081. https://doi.org/10.18632/oncotarget.11253
Rona, Germana B, et al. "The PWWP domain of the human oncogene WHSC1L1/NSD3 induces a metabolic shift toward fermentation." Oncotarget vol. 8,33 (2017): 54068-54081. doi: https://doi.org/10.18632/oncotarget.11253
Rona GB, Almeida DSG, Pinheiro AS, Eleutherio ECA. The PWWP domain of the human oncogene WHSC1L1/NSD3 induces a metabolic shift toward fermentation. Oncotarget. 2016 Aug 12;8(33):54068-54081. doi: 10.18632/oncotarget.11253. eCollection 2017 Aug 15. PMID: 28903324; PMCID: PMC5589563.
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Oncotarget. 2016 Aug 12;8(33):54068-54081. doi: 10.18632/oncotarget.11253. eCollection 2017 Aug 15.

The PWWP domain of the human oncogene WHSC1L1/NSD3 induces a metabolic shift toward fermentation.

Oncotarget

Germana B Rona, Diego S G Almeida, Anderson S Pinheiro, Elis C A Eleutherio

Affiliations

  1. Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, 21941-909, Rio de Janeiro, RJ, Brazil.

PMID: 28903324 PMCID: PMC5589563 DOI: 10.18632/oncotarget.11253

Abstract

WHSC1L1/NSD3, one of the most aggressive human oncogenes, has two isoforms derived from alternative splicing. Overexpression of long or short NSD3 is capable of transforming a healthy into a cancer cell. NSD3s, the short isoform, contains only a PWWP domain, a histone methyl-lysine reader involved in epigenetic regulation of gene expression. With the aim of understanding the NSD3s PWWP domain role in tumorigenesis, we used

Keywords: NSD3; PWWP; Pdp3; Saccharomyces cerevisiae; cancer

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no conflicts of interest.

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