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Koh KH, Tan CH, Hii LW, et al. Survival predictors in paraquat intoxification and role of immunosuppression. Toxicol Rep. 2014;1:490-495doi: 10.1016/j.toxrep.2014.06.010.
Koh, K. H., Tan, C. H., Hii, L. W., Lee, J., Ngu, L. L., Chai, A. J., Loh, C. L., Lam, S. W., Mushahar, L., Fam, T. L., & Yusuf, W. S. M. (2014). Survival predictors in paraquat intoxification and role of immunosuppression. Toxicology reports, 1490-495. https://doi.org/10.1016/j.toxrep.2014.06.010
Koh, Keng-Hee, et al. "Survival predictors in paraquat intoxification and role of immunosuppression." Toxicology reports vol. 1 (2014): 490-495. doi: https://doi.org/10.1016/j.toxrep.2014.06.010
Koh KH, Tan CH, Hii LW, Lee J, Ngu LL, Chai AJ, Loh CL, Lam SW, Mushahar L, Fam TL, Yusuf WSM. Survival predictors in paraquat intoxification and role of immunosuppression. Toxicol Rep. 2014 Jul 18;1:490-495. doi: 10.1016/j.toxrep.2014.06.010. eCollection 2014. PMID: 28962262; PMCID: PMC5598267.
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Toxicol Rep. 2014 Jul 18;1:490-495. doi: 10.1016/j.toxrep.2014.06.010. eCollection 2014.

Survival predictors in paraquat intoxification and role of immunosuppression.

Toxicology reports

Keng-Hee Koh, Clare Hui-Hong Tan, Lawrence Wei-Soon Hii, Jun Lee, Laura Lui-Sian Ngu, Alvin Jung-Mau Chai, Chek-Loong Loh, Swee-Win Lam, Lily Mushahar, Tem-Lom Fam, Wan Shaariah Md Yusuf

Affiliations

  1. Nephrology Unit and Department of Medicine, Sarawak General Hospital, Kuching, Malaysia.
  2. Nephrology Unit and Department of Medicine, Miri Hospital, Malaysia.
  3. Medical Department, Sibu Hospital, Malaysia.
  4. Medical Department, Hospital Raja Permaisuri Bainun, Ipoh, Malaysia.
  5. Medical Department, Hospital Sultan Abdul Halim, Sungai Petani, Malaysia.
  6. Nephrology Department, Hospital Tuanku Ja'afar, Seremban, Malaysia.

PMID: 28962262 PMCID: PMC5598267 DOI: 10.1016/j.toxrep.2014.06.010

Abstract

Paraquat poisoning resulted in multiorgan failure and is associated with high mortality. We audited 83 historical cases of paraquat poisoning in past 2 years treated with conventional decontamination and supportive treatment, followed by enrolling 85 patients over a 2 year period into additional immunosuppression with intravenous (i.v.) methylprednisolone and i.v. cyclophosphamide. Our results showed that age, poor renal function and leucocytosis are the main predictors of fatal outcome. Immunosuppression regime rendered higher survival (6 out of 17 patients (35.3%)) versus historical control (1 out of 18 patients (5.6%)) (

Keywords: Acute renal failure; Immunosuppression; Inflammation; Paraquat poisoning; Survival; eGFR

References

  1. QJM. 2003 Nov;96(11):809-24 - PubMed
  2. QJM. 1999 Oct;92(10):573-8 - PubMed
  3. Ann Intern Med. 1999 Mar 16;130(6):461-70 - PubMed
  4. Med Toxicol Adverse Drug Exp. 1988 Jan-Dec;3(1):64-71 - PubMed
  5. Crit Care Med. 2006 Feb;34(2):368-73 - PubMed
  6. Clin Toxicol (Phila). 2011 Jan;49(1):21-8 - PubMed
  7. QJM. 2009 Apr;102(4):251-9 - PubMed
  8. Hum Exp Toxicol. 1990 Jan;9(1):5-12 - PubMed
  9. Singapore Med J. 2010 Jun;51(6):496-500 - PubMed
  10. Arch Iran Med. 2008 Jul;11(4):387-91 - PubMed
  11. Am Rev Respir Dis. 1989 Mar;139(3):769-73 - PubMed
  12. Cochrane Database Syst Rev. 2010 Jun 16;(6):CD008084 - PubMed
  13. J Korean Med Sci. 2009 Jan;24 Suppl:S156-60 - PubMed
  14. Chest. 1995 Jan;107(1):285-9 - PubMed
  15. Nephrol Dial Transplant. 2009 Apr;24(4):1226-32 - PubMed
  16. PLoS Med. 2008 Feb;5(2):e58 - PubMed
  17. PLoS Med. 2008 Feb;5(2):e49 - PubMed
  18. Am J Kidney Dis. 2002 Jan;39(1):55-9 - PubMed
  19. Am J Respir Crit Care Med. 1999 Feb;159(2):357-60 - PubMed
  20. Singapore Med J. 2007 Nov;48(11):1000-5 - PubMed
  21. Thorax. 1996 Jul;51(7):661-3 - PubMed

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