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Toxicol Rep. 2014 Sep 04;1:834-842. doi: 10.1016/j.toxrep.2014.08.015. eCollection 2014.

[No title available]

Toxicology reports

Satyakumar Vidyashankar, Uddagiri Venkanna Babu, Pralhad Sadashiv Patki

Affiliations

  1. Cell Biology, Research and Development, The Himalaya Drug Company, Makali, Bangalore 562162, India.
  2. Phytochemistry, Research and Development, The Himalaya Drug Company, Makali, Bangalore 562162, India.
  3. Medical Services Clinical Trials, Research and Development, The Himalaya Drug Company, Makali, Bangalore 562162, India.

PMID: 28962295 PMCID: PMC5598397 DOI: 10.1016/j.toxrep.2014.08.015

Abstract

The accumulation of advanced glycation end products (AGE) plays significant role in developing tubular hypertrophy during diabetic nephropathy (DN). Reactive oxygen species and nitric oxide (NO) are directly involved in the progression of DN. We have studied the effect of standardized

Keywords: AGE, advanced glycation end products; Advanced glycation end products (AGE); Antioxidant enzymes; CAT, catalase; Cyclic GMP; DN, diabetic nephropathy; GE, Gymnemasylvestre organic extract; GPx, glutathione peroxidase; GSH, reduced glutathione; Glutathione; Gymnemasylvestre; LPO, lipid peroxidation; MDA, malondialdehyde; NO, nitric oxide; Nitric oxide; SOD, superoxide dismutase; cGMP, cyclic guanosine monophosphate

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