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Uphoff EP, Bird PK, Antó JM, et al. Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe. ERJ Open Res. 2017;3(3)doi: 10.1183/23120541.00150-2016.
Uphoff, E. P., Bird, P. K., Antó, J. M., Basterrechea, M., von Berg, A., Bergström, A., Bousquet, J., Chatzi, L., Fantini, M. P., Ferrero, A., Gehring, U., Gori, D., Heinrich, J., Keil, T., Kull, I., Lau, S., Maier, D., Momas, I., Narduzzi, S., Porta, D., Ranciere, F., Roumeliotaki, T., Schikowski, T., Smit, H. A., Standl, M., Sunyer, J., & Wright, J. (2017). Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe. ERJ open research, 3(3), . https://doi.org/10.1183/23120541.00150-2016
Uphoff, Eleonora P, et al. "Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe." ERJ open research vol. 3,3 (2017). doi: https://doi.org/10.1183/23120541.00150-2016
Uphoff EP, Bird PK, Antó JM, Basterrechea M, von Berg A, Bergström A, Bousquet J, Chatzi L, Fantini MP, Ferrero A, Gehring U, Gori D, Heinrich J, Keil T, Kull I, Lau S, Maier D, Momas I, Narduzzi S, Porta D, Ranciere F, Roumeliotaki T, Schikowski T, Smit HA, Standl M, Sunyer J, Wright J. Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe. ERJ Open Res. 2017 Jul 03;3(3). doi: 10.1183/23120541.00150-2016. eCollection 2017 Jul. PMID: 28845428; PMCID: PMC5566268.
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ERJ Open Res. 2017 Jul 03;3(3). doi: 10.1183/23120541.00150-2016. eCollection 2017 Jul.

Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe.

ERJ open research

Eleonora P Uphoff, Philippa K Bird, Joseph Maria Antó, Mikel Basterrechea, Andrea von Berg, Anna Bergström, Jean Bousquet, Leda Chatzi, Maria Pia Fantini, Amparo Ferrero, Ulrike Gehring, Davide Gori, Joachim Heinrich, Thomas Keil, Inger Kull, Susanne Lau, Dieter Maier, Isabelle Momas, Silvia Narduzzi, Daniela Porta, Fanny Ranciere, Theano Roumeliotaki, Tamara Schikowski, Henriette A Smit, Marie Standl, Jordi Sunyer, John Wright

Affiliations

  1. Bradford Institute for Health Research, Bradford, UK.
  2. Dept of Health Sciences, University of York, York, UK.
  3. Insituto de Salud Global Barcelona, Barcelona, Spain.
  4. CIBER Epidemiología y Salud Pública, Madrid, Spain.
  5. Subdirectorate of Public Health of Gipuzkoa, Basque Government, Dept of Health, Gipuzkoa, Spain.
  6. Health Research Institute BIODONOSTIA, Gipuzkoa, Spain.
  7. Dept of Pediatrics, Marien Hospital Wesel, Wesel, Germany.
  8. Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
  9. Centre Hôpital Universitaire de Montpellier, Montpellier, France.
  10. Dept of Social Medicine, University of Crete, Heraklion, Greece.
  11. Dipartimento di Scienze Biomediche e Neuromotorie, Universita degli Studi di Bologna, Bologna, Italy.
  12. FISABIO, Universitat de València-Universtitat Jaume I, Joint Research Unit, Valencia, Spain.
  13. Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
  14. Institute of Epidemiology, Helmholtz Zentrum München, Munich, Germany.
  15. Social Medicine, Epidemiology and Health Economics, Charité Medical University, Berlin, Germany.
  16. Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany.
  17. Biomax Informatics AG, Planegg, Germany.
  18. Université Paris Descartes, Paris, France.
  19. Dipartimento di Epidemiologia del SSR del Lazio, Rome, Italy.
  20. Leibniz-Institut für umweltmedizinische Forschung, Heinrich Heine Universitat, Düsseldorf, Germany.
  21. Julius Center for Health Sciences and Primary Care, Public Health, Health Technology Assessment, Medical Humanities, University Medical Center Utrecht, Utrecht, The Netherlands.

PMID: 28845428 PMCID: PMC5566268 DOI: 10.1183/23120541.00150-2016

Abstract

While there is evidence for variations in prevalence rates of childhood wheeze and asthma between countries, longitudinal, individual-level data are needed to understand these differences. The aim of this study was to examine variations in prevalence rates of childhood asthma, wheeze and wheeze with asthma in Europe. We analysed datasets from 10 MeDALL (Mechanisms of the Development of ALLergy) cohorts in eight countries, representing 26 663 children, to calculate prevalence rates of wheeze and asthma by child age and wheeze with asthma at age 4 years. Harmonised variables included outcomes parent-reported wheeze and parent-reported doctor-diagnosed asthma, and covariates maternal education, parental smoking, pets, parental asthma, doctor-diagnosed allergic rhinitis, doctor-diagnosed eczema and wheeze severity. At age 4 years, asthma prevalence varied from 1.72% in Germany to 13.48% in England and the prevalence of wheeze varied from 9.82% in Greece to 55.37% in Spain. Adjusted estimates of the proportion of 4-year-old children with wheeze diagnosed with asthma remained highest in England (38.14%, 95% CI 31.38-44.90%) and lowest in Spain (15.94%, 95% CI 6.16-25.71%). The large differences in prevalence rates of asthma, wheeze and wheeze with asthma at age 4 years between European cohorts may indicate that childhood asthma is more readily diagnosed in some countries while going unrecognised elsewhere.

Conflict of interest statement

Conflict of interest: Disclosures can be found alongside this article at openres.ersjournals.com

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