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Pan QM, Huang RZ, Pan YM, et al. [Studies on chemical constituents of rhizomes of Sophora tonkinensis]. Zhongguo Zhong Yao Za Zhi. 2016;41(1):96-100doi: 10.4268/cjcmm20160119.
Pan, Q. M., Huang, R. Z., Pan, Y. M., Wang, H. S., & Liang, D. (2016). [Studies on chemical constituents of rhizomes of Sophora tonkinensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 41(1), 96-100. https://doi.org/10.4268/cjcmm20160119
Pan, Qi-Ming, et al. "[Studies on chemical constituents of rhizomes of Sophora tonkinensis]." Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica vol. 41,1 (2016): 96-100. doi: https://doi.org/10.4268/cjcmm20160119
Pan QM, Huang RZ, Pan YM, Wang HS, Liang D. [Studies on chemical constituents of rhizomes of Sophora tonkinensis]. Zhongguo Zhong Yao Za Zhi. 2016 Jan;41(1):96-100. doi: 10.4268/cjcmm20160119. Chinese. PMID: 28845648.
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Zhongguo Zhong Yao Za Zhi. 2016 Jan;41(1):96-100. doi: 10.4268/cjcmm20160119.

[Studies on chemical constituents of rhizomes of Sophora tonkinensis].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Article in Chinese]
Qi-Ming Pan, Ri-Zhen Huang, Ying-Ming Pan, Heng-Shan Wang, Dong Liang

Affiliations

  1. State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.

PMID: 28845648 DOI: 10.4268/cjcmm20160119

Abstract

Thirteen compounds were isolated from the 95% aqueous EtOH extract of the rhizomes of Sophora tonkinensis by a combination of various chromatographic techniques including column chromatography over silica gel, Sphadex LH-20, MCI, ODS, and semi-preparative HPLC.Their structures were elucidated as 1-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl)ethanone(1), cyclo(Pro-Pro)(2), nicotinic acid(3), p-hydroxybenzonic acid(4), p-methoxybenzonic acid(5), 4-hydroxymethyl-2,6-dimethoxyphenol-1-O-β-D-glucopyranoside(6), coniferin(7), syringin(8),(-)-secoisolariciresinol-4-O-β-D-glucopyranoside(9),(-)-syringaresinol-4-O-β-D-glucopyranoside(10),(-)-syringaresinol-4,4'-di-O-β-D-glucopyranoside(11),(-)-pinoresinol-4,4'-di-O-β-D-glucopyranoside(12), and(6S,9R)-roseoside(13) by their physicochemical properties and spectroscopic data.Compound 1 was a new naturalproduct, and compounds 2,5,6,9,10,12 and 13 were obtained from the Sophora genus for the first time.Compound 1 possessed moderate cytotoxic activity against A549 human tumor cell [IC₅₀（23.05 ± 0.46）μmol•L⁻¹].

Copyright© by the Chinese Pharmaceutical Association.

Keywords: Sophora tonkinensis ; cytotoxic activity ; imidazoline alkaloid

Conflict of interest statement

The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.

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