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Berezin AE, Kremzer A, Berezina T, et al. The signature of circulating microparticles in heart failure patients with metabolic syndrome. J Circ Biomark. 2016;5:1849454416663659doi: 10.1177/1849454416663659.
Berezin, A. E., Kremzer, A., Berezina, T., & Martovitskaya, Y. (2016). The signature of circulating microparticles in heart failure patients with metabolic syndrome. Journal of circulating biomarkers, 51849454416663659. https://doi.org/10.1177/1849454416663659
Berezin, Alexander E, et al. "The signature of circulating microparticles in heart failure patients with metabolic syndrome." Journal of circulating biomarkers vol. 5 (2016): 1849454416663659. doi: https://doi.org/10.1177/1849454416663659
Berezin AE, Kremzer A, Berezina T, Martovitskaya Y. The signature of circulating microparticles in heart failure patients with metabolic syndrome. J Circ Biomark. 2016 Nov 10;5:1849454416663659. doi: 10.1177/1849454416663659. eCollection 2016. PMID: 28936261; PMCID: PMC5548327.
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J Circ Biomark. 2016 Nov 10;5:1849454416663659. doi: 10.1177/1849454416663659. eCollection 2016.

The signature of circulating microparticles in heart failure patients with metabolic syndrome.

Journal of circulating biomarkers

Alexander E Berezin, Alexander Kremzer, Tatyana Berezina, Yu Martovitskaya

Affiliations

  1. Consultant of the Therapeutic Unit, Internal Medicine Department, State Medical University, Zaporozhye, Ukraine.
  2. Private center Vita-Center, Zaporozhye, Ukraine.
  3. Pathology Department, Dia-Service LTD, Zaporozhye, Ukraine.

PMID: 28936261 PMCID: PMC5548327 DOI: 10.1177/1849454416663659

Abstract

The role of pattern of circulating endothelial cell-derived microparticles, platelet-derived microparticles (PMPs), and monocyte-derived microparticles (MMPs) in metabolic syndrome (MetS) patients with chronic heart failure (CHF) is not still understood. The aim of the study was to investigate a pattern of circulating microparticles (MPs) in MetS patients with CHF in relation to neurohumoral and inflammatory activation. The study retrospectively involved 101 patients with MetS and 35 healthy volunteers. Biomarkers were measured at baseline of the study. The results of the study have shown that numerous circulating PMPs- and MMPs in subjects with MetS (with or without CHF) insufficiently distinguished from level obtained in healthy volunteers. We found elevated level of CD31+/annexin V+ MPs in association with lower level of CD62E+ MPs. Therefore, we found that biomarkers of biomechanical stress serum N-terminal brain natriuretic peptide and inflammation (high-sensitive C-reactive protein ,osteoprotegerin) remain statistically significant predictors for decreased CD62E+ to CD31+/annexin V+ ratio in MetS patients with CHF. In conclusion, decreased CD62E+ to CD31+/annexin V+ ratio reflected that impaired immune phenotype of MPs may be discussed as a surrogate marker of CHF development in MetS population.

Keywords: Chronic heart failure; cardiovascular risk factors inflammation; circulating microparticles; metabolic syndrome; neurohumoral activation

Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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