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Front Microbiol. 2017 Aug 09;8:1513. doi: 10.3389/fmicb.2017.01513. eCollection 2017.

Molecular Epidemiology of Rubella Virus Strains Detected Around the Time of the 2012-2013 Epidemic in Japan.

Frontiers in microbiology

Yoshio Mori, Masahiro Miyoshi, Masayuki Kikuchi, Masao Sekine, Masahiro Umezawa, Miwako Saikusa, Yuki Matsushima, Masae Itamochi, Yoshihiro Yasui, Daiki Kanbayashi, Tatsuya Miyoshi, Kyoko Akiyoshi, Chika Tatsumi, Shuichi Zaitsu, Mayumi Kadoguchi, Noriyuki Otsuki, Kiyoko Okamoto, Masafumi Sakata, Katsuhiro Komase, Makoto Takeda

Affiliations

  1. Department of Virology 3, National Institute of Infectious DiseasesTokyo, Japan.
  2. Hokkaido Institute of Public HealthSapporo, Japan.
  3. Sapporo City Institute of Public HealthSapporo, Japan.
  4. Sendai City Institute of Public HealthSendai, Japan.
  5. Ibaraki Prefectural Institute of Public HealthIbaraki, Japan.
  6. Yokohama City Institute of Public HealthYokohama, Japan.
  7. Kawasaki City Institute for Public HealthKawasaki, Japan.
  8. Toyama Institute of HealthToyama, Japan.
  9. Aichi Prefectural Institute of Public HealthNagoya, Japan.
  10. Osaka Institute of Public HealthOsaka, Japan.
  11. Sakai City Institute of Public HealthSakai, Japan.
  12. Kobe Institute of HealthKobe, Japan.
  13. Shimane Prefectural Institute of Public Health and Environmental ScienceShimane, Japan.
  14. Fukuoka City Institute of Health and EnvironmentFukuoka, Japan.
  15. Kumamoto City Environmental Research CenterKumamoto, Japan.
  16. Kumamoto City HospitalKumamoto, Japan.
  17. Infectious Disease Surveillance Center, National Institute of Infectious DiseasesTokyo, Japan.

PMID: 28848523 PMCID: PMC5553008 DOI: 10.3389/fmicb.2017.01513

Abstract

A nationwide rubella epidemic occurred from 2012 to 2013 in Japan, resulting in around 17,000 rubella cases and the birth of 45 infants with congenital rubella syndrome. The aim of this study was to genetically characterize the rubella viruses (RVs) circulating around the time of the epidemic in Japan. In total, 221 RV strains detected from 14 prefectures in Japan between 2010 and 2014 were sequenced in the 739 nucleotide-window region within the

Keywords: Japan; epidemic; genotype; molecular epidemiology; rubella virus

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