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Front Immunol. 2017 Aug 10;8:893. doi: 10.3389/fimmu.2017.00893. eCollection 2017.

Effects of Bone Marrow Mesenchymal Stromal Cell Therapy in Experimental Cutaneous Leishmaniasis in BALB/c Mice Induced by .

Frontiers in immunology

Joyce Carvalho Pereira, Tadeu Diniz Ramos, Johnatas Dutra Silva, Mirian França de Mello, Juliana Elena Silveira Pratti, Alessandra Marcia da Fonseca-Martins, Luan Firmino-Cruz, Jamil Zola Kitoko, Suzana Passos Chaves, Daniel Claudio De Oliveira Gomes, Bruno Lourenço Diaz, Patricia R M Rocco, Herbert Leonel de Matos Guedes

Affiliations

  1. Laboratório de Inflamação, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  2. Laboratório de Investigação Pulmonar, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  3. Laboratório Integrado de Imunoparasitologia, Campus Macaé - Universidade Federal do Rio de Janeiro, Macaé, Brazil.
  4. Laboratório de Imunobiologia, Núcleo de Doenças Infecciosas/Núcleo de Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Brazil.
  5. Núcleo Multidisciplinar de Pesquisa UFRJ - Xerém em Biologia (NUMPEX-BIO), Polo Avançado de Xerém - Universidade Federal do Rio de Janeiro, Duque de Caxias, Brazil.
  6. Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

PMID: 28848541 PMCID: PMC5554126 DOI: 10.3389/fimmu.2017.00893

Abstract

Cutaneous leishmaniasis remains both a public health and a therapeutic challenge. To date, no ideal therapy for cutaneous leishmaniasis has been identified, and no universally accepted therapeutic regimen and approved vaccines are available. Due to the mesenchymal stromal cell (MSC) immunomodulatory capacity, they have been applied in a wide variety of disorders, including infectious, inflammatory, and allergic diseases. We evaluated the potential effects of bone marrow MSC therapy in a murine model of cutaneous leishmaniasis.

Keywords: BALB/c; IL-10; Leishmania amazonensis; Leishmaniasis; cell therapy; mesenchymal stromal cell

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