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Retamal-Díaz AR, Kalergis AM, Bueno SM, et al. A Herpes Simplex Virus Type 2 Deleted for Glycoprotein D Enables Dendritic Cells to Activate CD4. Front Immunol. 2017;8:904doi: 10.3389/fimmu.2017.00904.
Retamal-Díaz, A. R., Kalergis, A. M., Bueno, S. M., & González, P. A. (2017). A Herpes Simplex Virus Type 2 Deleted for Glycoprotein D Enables Dendritic Cells to Activate CD4. Frontiers in immunology, 8904. https://doi.org/10.3389/fimmu.2017.00904
Retamal-Díaz, Angello R, et al. "A Herpes Simplex Virus Type 2 Deleted for Glycoprotein D Enables Dendritic Cells to Activate CD4." Frontiers in immunology vol. 8 (2017): 904. doi: https://doi.org/10.3389/fimmu.2017.00904
Retamal-Díaz AR, Kalergis AM, Bueno SM, González PA. A Herpes Simplex Virus Type 2 Deleted for Glycoprotein D Enables Dendritic Cells to Activate CD4. Front Immunol. 2017 Aug 09;8:904. doi: 10.3389/fimmu.2017.00904. eCollection 2017. PMID: 28848543; PMCID: PMC5553038.
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Front Immunol. 2017 Aug 09;8:904. doi: 10.3389/fimmu.2017.00904. eCollection 2017.

A Herpes Simplex Virus Type 2 Deleted for Glycoprotein D Enables Dendritic Cells to Activate CD4.

Frontiers in immunology

Angello R Retamal-Díaz, Alexis M Kalergis, Susan M Bueno, Pablo A González

Affiliations

  1. Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
  2. Departamento de Endocrinología, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
  3. INSERM U1064, Nantes, France.

PMID: 28848543 PMCID: PMC5553038 DOI: 10.3389/fimmu.2017.00904

Abstract

Herpes simplex virus type 2 (HSV-2) is highly prevalent in the human population producing significant morbidity, mainly because of the generation of genital ulcers and neonatal encephalitis. Additionally, HSV-2 infection significantly increases the susceptibility of the host to acquire HIV and promotes the shedding of the latter in the coinfected. Despite numerous efforts to create a vaccine against HSV-2, no licensed vaccines are currently available. A long-standing strategy, based on few viral glycoproteins combined with adjuvants, recently displayed poor results in a Phase III clinical study fueling exploration on the development of mutant HSV viruses that are attenuated

Keywords: T cell activation; adaptive immunity; attenuation; dendritic cell function; dendritic cells; herpes simplex virus type 2; vaccine

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