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Ko HS, Suh YJ, Byun JW, et al. Pulsed Dye Laser Treatment Combined with Oral Minocycline Reduces Recurrence Rate of Rosacea. Ann Dermatol. 2017;29(5):543-547doi: 10.5021/ad.2017.29.5.543.
Ko, H. S., Suh, Y. J., Byun, J. W., Choi, G. S., & Shin, J. (2017). Pulsed Dye Laser Treatment Combined with Oral Minocycline Reduces Recurrence Rate of Rosacea. Annals of dermatology, 29(5), 543-547. https://doi.org/10.5021/ad.2017.29.5.543
Ko, Hye Soo, et al. "Pulsed Dye Laser Treatment Combined with Oral Minocycline Reduces Recurrence Rate of Rosacea." Annals of dermatology vol. 29,5 (2017): 543-547. doi: https://doi.org/10.5021/ad.2017.29.5.543
Ko HS, Suh YJ, Byun JW, Choi GS, Shin J. Pulsed Dye Laser Treatment Combined with Oral Minocycline Reduces Recurrence Rate of Rosacea. Ann Dermatol. 2017 Oct;29(5):543-547. doi: 10.5021/ad.2017.29.5.543. Epub 2017 Aug 25. PMID: 28966509; PMCID: PMC5597646.
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Ann Dermatol. 2017 Oct;29(5):543-547. doi: 10.5021/ad.2017.29.5.543. Epub 2017 Aug 25.

Pulsed Dye Laser Treatment Combined with Oral Minocycline Reduces Recurrence Rate of Rosacea.

Annals of dermatology

Hye Soo Ko, Young Ju Suh, Ji Won Byun, Gwang Seong Choi, Jeonghyun Shin

Affiliations

  1. Department of Dermatology, Inha University School of Medicine, Incheon, Korea.
  2. Department of Biomedical Sciences, Inha University School of Medicine, Incheon, Korea.

PMID: 28966509 PMCID: PMC5597646 DOI: 10.5021/ad.2017.29.5.543

Abstract

BACKGROUND: The recurrence rate of rosacea was not known very well, but has been reported as 60% in 6 months after withdrawal of the drug. It is not known which treatment can reduce relapses of rosacea effectively.

OBJECTIVE: The objective was to identify whether 595 nm-pulsed dye laser (PDL) treatment reduced recurrence rate among rosacea patients who were treated with oral minocycline.

METHODS: One hundred and seven Korean patients with rosacea who started treatment with oral minocycline (100 mg/d) with or without PDL (2∼4 sessions) were evaluated retrospectively. The recurrence rate was estimated using the Kaplan-Meier method, and difference was evaluated using the log-rank test. Cox proportional hazards model was used to estimate hazard ratios and 95% confidence intervals (CIs) of risk factors for the recurrence of rosacea.

RESULTS: The recurrence-free survival analysis revealed that the group with oral minocycline plus PDL was significantly different compared with the group with oral minocycline alone (

CONCLUSION: PDL can be used added to oral minocycline to reduce relapses among rosacea patients who are undergoing oral minocycline treatment.

Keywords: Minocycline; Pulsed dye laser; Recurrence; Rosacea; Therapeutics

Conflict of interest statement

CONFLICTS OF INTEREST: The authors have nothing to disclose.

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