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Nakae R, Yokobori S, Takayama Y, et al. Age-related differences in fibrinolytic parameters in patients with acute traumatic brain injury. Surg Neurol Int. 2017;8:214doi: 10.4103/sni.sni_56_17.
Nakae, R., Yokobori, S., Takayama, Y., Kuwamoto, K., Naoe, Y., & Yokota, H. (2017). Age-related differences in fibrinolytic parameters in patients with acute traumatic brain injury. Surgical neurology international, 8214. https://doi.org/10.4103/sni.sni_56_17
Nakae, Ryuta, et al. "Age-related differences in fibrinolytic parameters in patients with acute traumatic brain injury." Surgical neurology international vol. 8 (2017): 214. doi: https://doi.org/10.4103/sni.sni_56_17
Nakae R, Yokobori S, Takayama Y, Kuwamoto K, Naoe Y, Yokota H. Age-related differences in fibrinolytic parameters in patients with acute traumatic brain injury. Surg Neurol Int. 2017 Sep 06;8:214. doi: 10.4103/sni.sni_56_17. eCollection 2017. PMID: 28966820; PMCID: PMC5609444.
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Surg Neurol Int. 2017 Sep 06;8:214. doi: 10.4103/sni.sni_56_17. eCollection 2017.

Age-related differences in fibrinolytic parameters in patients with acute traumatic brain injury.

Surgical neurology international

Ryuta Nakae, Shoji Yokobori, Yasuhiro Takayama, Kentaro Kuwamoto, Yasutaka Naoe, Hiroyuki Yokota

Affiliations

  1. Emergency and Critical Care Center, Kawaguchi Municipal Medical Center, Kawaguchi-shi, Saitama, Japan.
  2. Department of Emergency and Critical Care Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.

PMID: 28966820 PMCID: PMC5609444 DOI: 10.4103/sni.sni_56_17

Abstract

BACKGROUND: Coagulopathy and old age have been associated with poor outcomes in traumatic brain injury (TBI) patients; however, the relationships of coagulopathy and age with the acute phase of TBI remain unclear. We hypothesized that coagulation/fibrinolytic abnormalities are more severe in older patients in the acute phase of TBI and may explain, in part, their poor outcome.

METHODS: We analyzed the relationship between coagulation/fibrinolytic parameters and age in the acute phase of TBI by retrospectively evaluating 274 patients with initial blood samples obtained no more than 1 hour after injury. Measurement of platelet count, prothrombin time, activated partial thromboplastin time, plasma levels of fibrinogen, and D-dimer was done in the emergency department on arrival as well as 3, 6, and 12 hours following injury. Values were compared between patients aged 16-55 years (group 1) and those aged older than 55 years (group 2) with an Abbreviated Injury Score (AIS)-head of 3-5 to identify any relationship between these parameters and age.

RESULTS: When groups 1 and 2 were matched for AIS-head, plasma levels of D-dimer in group 2 were significantly higher than those in group 1 from hospital admission to 12 hours after injury. The Glasgow Outcome Scale scores at 3 months post-injury of group 2 with AIS 4 and 5 were significantly lower than those of group 1 (both

CONCLUSIONS: Fibrinolytic abnormalities are more severe in older acute-phase TBI patients, which may be a factor associated with their poor prognosis.

Keywords: Age; D-dimer; coagulopathy; fibrinolysis; traumatic brain injury

Conflict of interest statement

There are no conflicts of interest.

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