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Wang CC, Ho CT, Lee SC, et al. Isolation of eugenyl β-primeveroside from Camellia sasanqua and its anticancer activity in PC3 prostate cancer cells. J Food Drug Anal. 2015;24(1):105-111doi: 10.1016/j.jfda.2015.06.005.
Wang, C. C., Ho, C. T., Lee, S. C., & Way, T. D. (2016). Isolation of eugenyl β-primeveroside from Camellia sasanqua and its anticancer activity in PC3 prostate cancer cells. Journal of food and drug analysis, 24(1), 105-111. https://doi.org/10.1016/j.jfda.2015.06.005
Wang, Chun-Chieh, et al. "Isolation of eugenyl β-primeveroside from Camellia sasanqua and its anticancer activity in PC3 prostate cancer cells." Journal of food and drug analysis vol. 24,1 (2016): 105-111. doi: https://doi.org/10.1016/j.jfda.2015.06.005
Wang CC, Ho CT, Lee SC, Way TD. Isolation of eugenyl β-primeveroside from Camellia sasanqua and its anticancer activity in PC3 prostate cancer cells. J Food Drug Anal. 2016 Jan;24(1):105-111. doi: 10.1016/j.jfda.2015.06.005. Epub 2015 Jul 28. PMID: 28911392.
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J Food Drug Anal. 2016 Jan;24(1):105-111. doi: 10.1016/j.jfda.2015.06.005. Epub 2015 Jul 28.

Isolation of eugenyl β-primeveroside from Camellia sasanqua and its anticancer activity in PC3 prostate cancer cells.

Journal of food and drug analysis

Chun-Chieh Wang, Chi-Tang Ho, Shih-Chieh Lee, Tzong-Der Way

Affiliations

  1. Department of Bioindustry Technology, Dayeh University, Changhua, Taiwan.
  2. Department of Food Science, Rutgers University, New Brunswick, NJ, USA.
  3. Department of Bioindustry Technology, Dayeh University, Changhua, Taiwan. Electronic address: [email protected].
  4. Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan; Institute of Biochemistry, College of Life Science, National Chung Hsing University, Taichung, Taiwan; Department of Health and Nutrition Biotechnology, College of Health Science, Asia University, Taichung, Taiwan. Electronic address: [email protected].

PMID: 28911392 DOI: 10.1016/j.jfda.2015.06.005

Abstract

Most studies of tea trees have focused on their ornamental properties, there are fewer published studies on their medical values. The purpose of this study was to compare the chemical constituents and the biological potential of the water extract of leaves in eight species of Camellia including Camellia sinensis. Among eight Camellia species, Camellia sasanqua showed potent anticancer activities in prostate cancer PC3 cells. In addition to catechins, the major component, eugenyl β-primeveroside was detected in C. sasanqua. Eugenyl β-primeveroside blocked the progression of cell cycle at G1 phase by inducing p53 expression and further upregulating p21 expression. Moreover, eugenyl β-primeveroside induced apoptosis in PC3 prostate cancer cells. Our results suggest that C. sasanqua may have anticancer potential.

Copyright © 2015. Published by Elsevier B.V.

Keywords: Camellia sasanqua; G1 arrest; apoptosis; eugenyl β-primeveroside; prostate cancer

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