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Wu SH, Sun NN, Chau CF. Microspheres as carriers for lipase inhibitory substances to reduce dietary triglyceride absorption in mice. J Food Drug Anal. 2015;24(1):129-135doi: 10.1016/j.jfda.2015.08.002.
Wu, S. H., Sun, N. N., & Chau, C. F. (2016). Microspheres as carriers for lipase inhibitory substances to reduce dietary triglyceride absorption in mice. Journal of food and drug analysis, 24(1), 129-135. https://doi.org/10.1016/j.jfda.2015.08.002
Wu, Shiuan-Huei, et al. "Microspheres as carriers for lipase inhibitory substances to reduce dietary triglyceride absorption in mice." Journal of food and drug analysis vol. 24,1 (2016): 129-135. doi: https://doi.org/10.1016/j.jfda.2015.08.002
Wu SH, Sun NN, Chau CF. Microspheres as carriers for lipase inhibitory substances to reduce dietary triglyceride absorption in mice. J Food Drug Anal. 2016 Jan;24(1):129-135. doi: 10.1016/j.jfda.2015.08.002. Epub 2015 Oct 16. PMID: 28911395.
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J Food Drug Anal. 2016 Jan;24(1):129-135. doi: 10.1016/j.jfda.2015.08.002. Epub 2015 Oct 16.

Microspheres as carriers for lipase inhibitory substances to reduce dietary triglyceride absorption in mice.

Journal of food and drug analysis

Shiuan-Huei Wu, Nan-Nong Sun, Chi-Fai Chau

Affiliations

  1. Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan.
  2. Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan; Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan. Electronic address: [email protected].

PMID: 28911395 DOI: 10.1016/j.jfda.2015.08.002

Abstract

The present study intends to use microspheres as a delivery system of chlorogenic acid (CGA) to investigate the influences of CGA microspheres on dietary fat absorption and fecal triglyceride excretion in a mice model. Microspheres have an average particle size of about 53.3 μm. Results indicated that the microspheres were capable of gradually releasing the preloaded CGA into the surrounding medium. Their bioadhesive property might help prolong the gastrointestinal transit time in mice, and render a better mixing and contact between CGA and triglyceride. Consumption of CGA microspheres resulted in a significantly higher level of fecal triglyceride (119-144%) as compared with the corresponding control groups. A microsphere would be a desirable vehicle for CGA to improve its efficacy along the intestine.

Copyright © 2015. Published by Elsevier B.V.

Keywords: bioadhesive property; carrier; chlorogenic acid; microsphere; triglyceride

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