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Mana MD, Kuo EY, Yilmaz ÖH. Dietary Regulation of Adult Stem Cells. Curr Stem Cell Rep. 2017;3(1):1-8doi: 10.1007/s40778-017-0072-x.
Mana, M. D., Kuo, E. Y., & Yilmaz, �. �. H. (2017). Dietary Regulation of Adult Stem Cells. Current stem cell reports, 3(1), 1-8. https://doi.org/10.1007/s40778-017-0072-x
Mana, Miyeko D, et al. "Dietary Regulation of Adult Stem Cells." Current stem cell reports vol. 3,1 (2017): 1-8. doi: https://doi.org/10.1007/s40778-017-0072-x
Mana MD, Kuo EY, Yilmaz ÖH. Dietary Regulation of Adult Stem Cells. Curr Stem Cell Rep. 2017 Mar;3(1):1-8. doi: 10.1007/s40778-017-0072-x. Epub 2017 Feb 08. PMID: 28966904; PMCID: PMC5614456.
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Curr Stem Cell Rep. 2017 Mar;3(1):1-8. doi: 10.1007/s40778-017-0072-x. Epub 2017 Feb 08.

Dietary Regulation of Adult Stem Cells.

Current stem cell reports

Miyeko D Mana, Elaine Yih-Shuen Kuo, Ömer H Yilmaz

Affiliations

  1. The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, Department of Biology, MIT, Cambridge, MA 02139 USA.
  2. Broad Institute of Harvard and MIT, Cambridge, MA 02142 USA.
  3. Departments of Pathology, Gastroenterology, and Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 USA.

PMID: 28966904 PMCID: PMC5614456 DOI: 10.1007/s40778-017-0072-x

Abstract

PURPOSE OF REVIEW: Dietary intake is a critical regulator of organismal physiology and health. Tissue homeostasis and regeneration are dependent on adult tissue stem cells that self-renew and differentiate into the specialized cell types. As stem cells respond to cues from their environment, dietary signals and nutrients influence tissue biology by altering the function and activity of adult stem cells. In this review, we highlight recent studies that illustrate how diverse diets such as caloric restriction, fasting, high fat diets, and ketogenic diets impact stem cell function and their microenvironments.

RECENT FINDINGS: Caloric restriction generally exerts positive effects on adult stem cells, notably increasing stem cell functionality in the intestine and skeletal muscle as well as increasing hematopoietic stem cell quiescence. Similarly, fasting confers protection of intestinal, hematopoietic, and neuronal stem cells against injury. High fat diets induce intestinal stem cell niche independence and stem-like properties in intestinal progenitors, while high fat diets impair hematopoiesis and neurogenesis.

SUMMARY: Caloric restriction and fasting are generally beneficial to adult stem cell function, while high fat diets impair stem cell function or create opportunities for tumorigenesis. However, the effects of each diet on stem cell biology are complex and vary greatly between tissues. Given the recent interest in developing dietary interventions or mimetics as therapeutics, further studies, including on ketogenic diets, will be essential to understand how adult stem cells respond to diet-induced signals and physiology.

Keywords: Diet; mammalian adult stem cells

Conflict of interest statement

Conflict of Interest Miyeko D. Mana, Elaine Yih-Shuen Kuo, and Ömer H. Yilmaz declare that they have no conflict of interest.

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