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Thornton C, Leaw B, Mallard C, et al. Cell Death in the Developing Brain after Hypoxia-Ischemia. Front Cell Neurosci. 2017;11:248doi: 10.3389/fncel.2017.00248.
Thornton, C., Leaw, B., Mallard, C., Nair, S., Jinnai, M., & Hagberg, H. (2017). Cell Death in the Developing Brain after Hypoxia-Ischemia. Frontiers in cellular neuroscience, 11248. https://doi.org/10.3389/fncel.2017.00248
Thornton, Claire, et al. "Cell Death in the Developing Brain after Hypoxia-Ischemia." Frontiers in cellular neuroscience vol. 11 (2017): 248. doi: https://doi.org/10.3389/fncel.2017.00248
Thornton C, Leaw B, Mallard C, Nair S, Jinnai M, Hagberg H. Cell Death in the Developing Brain after Hypoxia-Ischemia. Front Cell Neurosci. 2017 Aug 23;11:248. doi: 10.3389/fncel.2017.00248. eCollection 2017. PMID: 28878624; PMCID: PMC5572386.
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Front Cell Neurosci. 2017 Aug 23;11:248. doi: 10.3389/fncel.2017.00248. eCollection 2017.

Cell Death in the Developing Brain after Hypoxia-Ischemia.

Frontiers in cellular neuroscience

Claire Thornton, Bryan Leaw, Carina Mallard, Syam Nair, Masako Jinnai, Henrik Hagberg

Affiliations

  1. Division of Imaging Sciences and Biomedical Engineering, Centre for the Developing Brain, King's College London, King's Health Partners, St. Thomas' HospitalLondon, United Kingdom.
  2. The Ritchie Centre, Hudson Institute of Medical ResearchClayton, VIC, Australia.
  3. Department of Physiology, Perinatal Center, Institute of Physiology and Neuroscience, Sahlgrenska Academy, University of GothenburgGothenburg, Sweden.
  4. Department of Clinical Sciences and Physiology and Neuroscience, Perinatal Center, Sahlgrenska Academy, Gothenburg UniversityGothenburg, Sweden.

PMID: 28878624 PMCID: PMC5572386 DOI: 10.3389/fncel.2017.00248

Abstract

Perinatal insults such as hypoxia-ischemia induces secondary brain injury. In order to develop the next generation of neuroprotective therapies, we urgently need to understand the underlying molecular mechanisms leading to cell death. The cell death mechanisms have been shown to be quite different in the developing brain compared to that in the adult. The aim of this review is update on what cell death mechanisms that are operating particularly in the setting of the developing CNS. In response to mild stress stimuli a number of compensatory mechanisms will be activated, most often leading to cell survival. Moderate-to-severe insults trigger regulated cell death. Depending on several factors such as the metabolic situation, cell type, nature of the stress stimulus, and which intracellular organelle(s) are affected, the cell undergoes apoptosis (caspase activation) triggered by BAX dependent mitochondrial permeabilzation, necroptosis (mixed lineage kinase domain-like activation), necrosis (via opening of the mitochondrial permeability transition pore), autophagic cell death (autophagy/Na

Keywords: apoptosis; hypoxia-ischemia; mitochondria; necroptosis; necrosis; perinatal brain injury

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