Display options
Share it on

Front Immunol. 2017 Aug 23;8:1016. doi: 10.3389/fimmu.2017.01016. eCollection 2017.

Zika Virus Promotes Neuronal Cell Death in a Non-Cell Autonomous Manner by Triggering the Release of Neurotoxic Factors.

Frontiers in immunology

Isabella G Olmo, Toniana G Carvalho, Vivian V Costa, Juliana Alves-Silva, Carolina Z Ferrari, Tatiane C Izidoro-Toledo, Juliana F da Silva, Antonio L Teixeira, Danielle G Souza, Joao T Marques, Mauro M Teixeira, Luciene B Vieira, Fabiola M Ribeiro

Affiliations

  1. Department of Biochemistry and Immunology, Institute of Biological Sciences (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
  2. Department of Pharmacology, ICB, UFMG, Belo Horizonte, Brazil.
  3. Institute of Education and Research Santa Casa, Belo Horizonte, Brazil.
  4. Neuropsychiatry Program, Department of Psychiatry and Behavioral Science, UT Health, Houston, TX, United States.
  5. Department of Microbiology, ICB, UFMG, Belo Horizonte, Brazil.

PMID: 28878777 PMCID: PMC5572413 DOI: 10.3389/fimmu.2017.01016

Abstract

Zika virus (ZIKV) has recently caused a worldwide outbreak of infections associated with severe neurological complications, including microcephaly in infants born from infected mothers. ZIKV exhibits high neurotropism and promotes neuroinflammation and neuronal cell death. We have recently demonstrated that

Keywords: GluN2B; N-methyl-d-aspartate receptors; Zika virus; interleukin-1β; tumor necrosis factor-α

References

  1. J Neurochem. 2007 Mar;100(5):1407-20 - PubMed
  2. Nat Rev Neurosci. 2004 Mar;5(3):173-83 - PubMed
  3. Glia. 2012 Mar;60(3):487-501 - PubMed
  4. MBio. 2017 Apr 25;8(2):null - PubMed
  5. FEBS Lett. 2001 Jun 29;500(1-2):17-24 - PubMed
  6. J Neurochem. 2008 May;105(4):1276-86 - PubMed
  7. Trans R Soc Trop Med Hyg. 1952 Sep;46(5):509-20 - PubMed
  8. ScientificWorldJournal. 2012;2012:267120 - PubMed
  9. J Physiol. 2006 May 1;572(Pt 3):789-98 - PubMed
  10. J Neurosci. 1992 May;12(5):1882-95 - PubMed
  11. PLoS Genet. 2009 Aug;5(8):e1000604 - PubMed
  12. J Neuroimmunol. 1997 Oct;79(1):84-90 - PubMed
  13. Emerg Infect Dis. 2014 Jun;20(6):1085-6 - PubMed
  14. N Engl J Med. 2016 Dec 15;375(24):2321-2334 - PubMed
  15. J Virol. 2000 Jul;74(14):6433-41 - PubMed
  16. Science. 2016 May 13;352(6287):816-8 - PubMed
  17. J Biol Chem. 2001 Jan 26;276(4):2627-36 - PubMed
  18. Neuroscience. 2009 Jan 12;158(1):334-43 - PubMed
  19. Int J Infect Dis. 2016 Mar;44:11-5 - PubMed
  20. FASEB J. 2008 Dec;22(12):4258-71 - PubMed
  21. J Physiol. 2007 Oct 15;584(Pt 2):509-19 - PubMed
  22. Sci Rep. 2016 Oct 07;6:34793 - PubMed
  23. Exp Physiol. 2005 Sep;90(5):663-70 - PubMed
  24. J Neuroinflammation. 2013 Dec 17;10:153 - PubMed
  25. J Neurosci. 2009 Apr 8;29(14):4420-9 - PubMed
  26. Lancet Infect Dis. 2016 Dec;16(12 ):1356-1363 - PubMed
  27. Science. 1993 Apr 9;260(5105):181-6 - PubMed
  28. BMJ. 2016 Feb 02;352:i657 - PubMed
  29. N Engl J Med. 2016 Mar 10;374(10 ):951-8 - PubMed
  30. MMWR Morb Mortal Wkly Rep. 2016 Dec 16;65(49):1409-1413 - PubMed
  31. Neuron. 1994 Mar;12(3):529-40 - PubMed
  32. J Biol Chem. 2006 Jul 28;281(30):21362-8 - PubMed
  33. PLoS Med. 2017 Jan 3;14 (1):e1002203 - PubMed
  34. J Neurophysiol. 2006 Mar;95(3):1727-34 - PubMed
  35. J Neurosci. 1999 May 15;19(10):4180-8 - PubMed
  36. J Virol. 2003 Dec;77(24):13203-13 - PubMed
  37. J Neurosci. 2005 Apr 27;25(17):4279-87 - PubMed
  38. Nat Rev Neurosci. 2010 Oct;11(10):682-96 - PubMed
  39. J Autoimmun. 2016 Apr;68:1-13 - PubMed
  40. Br J Pharmacol. 2013 Jun;169(4):909-21 - PubMed
  41. N Engl J Med. 2016 Oct 20;375(16):1598-1601 - PubMed
  42. Stroke. 1994 Jul;25(7):1481-8 - PubMed
  43. Sci Rep. 2017 Jan 23;7:40780 - PubMed
  44. J Neurosci. 2003 Sep 24;23(25):8692-700 - PubMed
  45. Lancet. 2016 May 21;387(10033):2125-2132 - PubMed
  46. Clin Infect Dis. 2017 Apr 1;64(7):914-920 - PubMed
  47. Arch Virol. 2002 Jun;147(6):1105-19 - PubMed
  48. MMWR Morb Mortal Wkly Rep. 2016 Feb 19;65(6):159-60 - PubMed
  49. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18769-74 - PubMed
  50. J Virol. 1997 Aug;71(8):5963-71 - PubMed
  51. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2808-13 - PubMed
  52. Neuron. 2005 Jun 2;46(5):745-60 - PubMed
  53. Lancet. 2016 Jan 16;387(10015):228 - PubMed
  54. J Neurosci. 2007 Mar 14;27(11):2846-57 - PubMed
  55. Mediators Inflamm. 2014;2014:861231 - PubMed
  56. Trends Pharmacol Sci. 1995 Oct;16(10):356-9 - PubMed
  57. J Virol. 2002 May;76(9):4162-71 - PubMed
  58. Lancet. 2016 Apr 9;387(10027):1531-1539 - PubMed
  59. Nat Rev Neurosci. 2013 Jun;14(6):383-400 - PubMed
  60. Med Microbiol Immunol. 2014 Aug;203(4):231-50 - PubMed
  61. J Neurosci. 2000 Jun 15;20(12):4573-81 - PubMed
  62. J Neuroimmunol. 2017 Jun 15;307:7-13 - PubMed
  63. J Neurochem. 1987 Jul;49(1):50-7 - PubMed
  64. Lancet Infect Dis. 2016 Jun;16(6):653-660 - PubMed
  65. Nature. 2016 May 11;534(7606):267-71 - PubMed
  66. Curr Opin Neurobiol. 2003 Jun;13(3):366-71 - PubMed
  67. Nat Neurosci. 2002 May;5(5):405-14 - PubMed
  68. Nat Med. 2016 Oct;22(10 ):1101-1107 - PubMed
  69. PLoS Negl Trop Dis. 2016 Feb 25;10(2):e0004517 - PubMed
  70. J Neurosci. 2010 Feb 17;30(7):2623-35 - PubMed
  71. Cell Stem Cell. 2016 May 5;18(5):587-90 - PubMed
  72. Nucleic Acids Res. 2007 Jul;35(Web Server issue):W71-4 - PubMed
  73. Neuron. 2007 Feb 15;53(4):549-62 - PubMed
  74. Cell Stem Cell. 2016 Jul 7;19(1):120-6 - PubMed
  75. J Neuroinflammation. 2010 Oct 31;7:73 - PubMed
  76. N Engl J Med. 2009 Jun 11;360(24):2536-43 - PubMed

Publication Types