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Kun S, Duan Q, Liu G, et al. Prognostic value of DNA repair genes based on stratification of glioblastomas. Oncotarget. 2017;8(35):58222-58230doi: 10.18632/oncotarget.17452.
Kun, S., Duan, Q., Liu, G., & Lu, J. M. (2017). Prognostic value of DNA repair genes based on stratification of glioblastomas. Oncotarget, 8(35), 58222-58230. https://doi.org/10.18632/oncotarget.17452
Kun, Sun, et al. "Prognostic value of DNA repair genes based on stratification of glioblastomas." Oncotarget vol. 8,35 (2017): 58222-58230. doi: https://doi.org/10.18632/oncotarget.17452
Kun S, Duan Q, Liu G, Lu JM. Prognostic value of DNA repair genes based on stratification of glioblastomas. Oncotarget. 2017 Apr 27;8(35):58222-58230. doi: 10.18632/oncotarget.17452. eCollection 2017 Aug 29. PMID: 28938550; PMCID: PMC5601646.
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Oncotarget. 2017 Apr 27;8(35):58222-58230. doi: 10.18632/oncotarget.17452. eCollection 2017 Aug 29.

Prognostic value of DNA repair genes based on stratification of glioblastomas.

Oncotarget

Sun Kun, Qiwen Duan, Gang Liu, Jing-Min Lu

Affiliations

  1. Department of Neurosurgery, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
  2. Department of Oncology, Taihe Hospital, Hubei University of Medicine, Hubei, China.
  3. Department of Orthopedics, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
  4. Department of Neurology, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, China.

PMID: 28938550 PMCID: PMC5601646 DOI: 10.18632/oncotarget.17452

Abstract

Abnormal expression of DNA repair genes is frequently associated with cancerogenesis of many tumors, however, the role DNA repair genes play in the progression of glioblastoma remains unclear. In this study, taking advantage of large scale of RNA-seq data, as well as clinical data, the function and prognosis value of key DNA repair genes in glioblastoma were analyzed by systematically bioinformatic approaches. Clustering was performed to screen potentially abnormal DNA repair genes related to the prognosis of glioblastoma, followed by unsupervised clustering to identify molecular subtypes of glioblastomas. Characteristics and prognosis differences were analyzed among these molecular subtypes, and modular driver genes in molecular subtypes were identified based on changes in expression correlation. Multifactor Cox proportional hazard analysis was used to find the independent prognostic factor. A total of 15 key genes, which were significantly related to prognosis, were identified and four molecular subtypes of disease were obtained through unsupervised clustering, based on these 15 genes. By analyzing the clinical features of these 4 molecular subtypes, Cluster 4 was found to be different from others in terms of age and prognosis level. A total of 5 key DNA repair genes, CDK7, DDB2, RNH1, RFC2 and FAH, were screened to be significantly related to the prognosis of glioblastomas (

Keywords: COX; Kaplan-Meier; glioblastoma multiforme; prognosis

Conflict of interest statement

CONFLICTS OF INTEREST None.

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