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Appels A. Inflammation and the mental state before an acute coronary event. Ann Med. 1999;31:41-44doi: 10.1080/07853890.1999.11904398.
Appels, A. (1999). Inflammation and the mental state before an acute coronary event. Annals of medicine, 3141-44. https://doi.org/10.1080/07853890.1999.11904398
Appels, Ad. "Inflammation and the mental state before an acute coronary event." Annals of medicine vol. 31 (1999): 41-44. doi: https://doi.org/10.1080/07853890.1999.11904398
Appels A. Inflammation and the mental state before an acute coronary event. Ann Med. 1999;31:41-44. doi: 10.1080/07853890.1999.11904398. PMID: 28850278.
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Ann Med. 1999;31:41-44. doi: 10.1080/07853890.1999.11904398.

Inflammation and the mental state before an acute coronary event.

Annals of medicine

Ad Appels

Affiliations

  1. a Department of Medical Psychology , University of Maastricht , Maastricht , The Netherlands .

PMID: 28850278 DOI: 10.1080/07853890.1999.11904398

Abstract

Feelings of exhaustion have been found to belong to the precursors of acute coronary events. Guided by the current views of the pathogenesis of acute coronary syndromes, a two-stage model describing a feedback relationship between mental state and the disease process is presented. According to the presented model prolonged exposure to stress results in a state of exhaustion leading to increased susceptibility to inflammatory diseases. Inflammation, in turn, amplifies feelings of exhaustion and malaise through cytokine release. Results of a study of 15 exhausted and 15 nonexhausted angioplasty patients, showing elevated levels of interleukin-1β and tumour necrosis factor-α in the exhausted patients, give empirical support to this model.

Keywords: acute coronary events; cytokines; depression; inflammation; vital exhaustion

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