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Marzin T, Lorkowski G, Reule C, et al. Effects of a systemic enzyme therapy in healthy active adults after exhaustive eccentric exercise: a randomised, two-stage, double-blinded, placebo-controlled trial. BMJ Open Sport Exerc Med. 2017;2(1):e000191doi: 10.1136/bmjsem-2016-000191.
Marzin, T., Lorkowski, G., Reule, C., Rau, S., Pabst, E., Vester, J. C., & Pabst, H. (2016). Effects of a systemic enzyme therapy in healthy active adults after exhaustive eccentric exercise: a randomised, two-stage, double-blinded, placebo-controlled trial. BMJ open sport & exercise medicine, 2(1), e000191. https://doi.org/10.1136/bmjsem-2016-000191
Marzin, Tobias, et al. "Effects of a systemic enzyme therapy in healthy active adults after exhaustive eccentric exercise: a randomised, two-stage, double-blinded, placebo-controlled trial." BMJ open sport & exercise medicine vol. 2,1 (2016): e000191. doi: https://doi.org/10.1136/bmjsem-2016-000191
Marzin T, Lorkowski G, Reule C, Rau S, Pabst E, Vester JC, Pabst H. Effects of a systemic enzyme therapy in healthy active adults after exhaustive eccentric exercise: a randomised, two-stage, double-blinded, placebo-controlled trial. BMJ Open Sport Exerc Med. 2017 Mar 12;2(1):e000191. doi: 10.1136/bmjsem-2016-000191. eCollection 2016. PMID: 28879033; PMCID: PMC5569274.
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BMJ Open Sport Exerc Med. 2017 Mar 12;2(1):e000191. doi: 10.1136/bmjsem-2016-000191. eCollection 2016.

Effects of a systemic enzyme therapy in healthy active adults after exhaustive eccentric exercise: a randomised, two-stage, double-blinded, placebo-controlled trial.

BMJ open sport & exercise medicine

Tobias Marzin, Gerhard Lorkowski, Claudia Reule, Stefanie Rau, Elisabeth Pabst, Johannes C Vester, Helmut Pabst

Affiliations

  1. Zentrum für Leistungsdiagnostik, Sportschule Fuerstenfeldbruck-Puch Gmbh, Fuerstenfeldbruck, Germany.
  2. GL Pharma Consulting Research & Development, Gauting, Germany.
  3. BioTeSys GmbH, Esslingen, Germany.
  4. Mucos Pharma GmbH & Co. KG, Unterhaching, Germany.
  5. Sportmedizin, Gilching, Germany.
  6. IDV Data Analysis and Study Planning, Krailling, Germany.

PMID: 28879033 PMCID: PMC5569274 DOI: 10.1136/bmjsem-2016-000191

Abstract

BACKGROUND: Systemic enzyme therapy may improve symptoms of exhaustive eccentric exercise due to anti-inflammatory properties.

METHODS: In a randomised, placebo-controlled, two-stage clinical trial, systemic enzyme therapy (Wobenzym) was administered for 72 hours before and 72 hours following a day on which subjects performed an exhaustive eccentric exercise (isokinetic loading of the quadriceps). Efficacy criteria (maximal strength and pain) and time points were selected to account for the multidimensional nature of exercise-induced muscle damage symptoms. Subjects were randomised in a crossover (stage I, n=28) and parallel group design (stage II, n=44).

RESULTS: Analysis of stage I data demonstrated a significant superiority (Mann-Whitney=0.6153; p=0.0332; one sided) for systemic enzyme therapy compared with placebo. Stage II was designed as a randomised controlled parallel group comparison. Heterogeneity (I

CONCLUSION: Systemic enzyme therapy before and after exhaustive eccentric exercise resulted in higher maximal concentric strength in the less strength-trained subjects (stage I) and in significant favourable effects on biomarkers (inflammatory, metabolic and immune) in all subjects. The application of these findings needs further evaluation.

Keywords: Muscle injury and inflammation; exercise; proteolytic enzymes; recovery

Conflict of interest statement

Competing interests: GL works among several others as consultant for Mucos Pharma GmbH & Co. KG. Mucos Pharma GmbH & Co. KG has contributed the product needed for intervention and funded the trial wit

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