Display options
Cite
Yang P, Chen X, Zeng L, et al. The response of the Oxford classification to steroid in IgA nephropathy: a systematic review and meta-analysis. Oncotarget. 2017;8(35):59748-59756doi: 10.18632/oncotarget.19574.
Yang, P., Chen, X., Zeng, L., Hao, H., & Xu, G. (2017). The response of the Oxford classification to steroid in IgA nephropathy: a systematic review and meta-analysis. Oncotarget, 8(35), 59748-59756. https://doi.org/10.18632/oncotarget.19574
Yang, Pingping, et al. "The response of the Oxford classification to steroid in IgA nephropathy: a systematic review and meta-analysis." Oncotarget vol. 8,35 (2017): 59748-59756. doi: https://doi.org/10.18632/oncotarget.19574
Yang P, Chen X, Zeng L, Hao H, Xu G. The response of the Oxford classification to steroid in IgA nephropathy: a systematic review and meta-analysis. Oncotarget. 2017 Jul 26;8(35):59748-59756. doi: 10.18632/oncotarget.19574. eCollection 2017 Aug 29. PMID: 28938678; PMCID: PMC5601774.
Copy Download .nbib Format: NLM
Share it on

Oncotarget. 2017 Jul 26;8(35):59748-59756. doi: 10.18632/oncotarget.19574. eCollection 2017 Aug 29.

The response of the Oxford classification to steroid in IgA nephropathy: a systematic review and meta-analysis.

Oncotarget

Pingping Yang, Xi Chen, Lei Zeng, Hua Hao, Gaosi Xu

Affiliations

  1. Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
  2. Grade 2013, The Second Clinical Medical College of Nanchang University, Nanchang, China.
  3. Department of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

PMID: 28938678 PMCID: PMC5601774 DOI: 10.18632/oncotarget.19574

Abstract

BACKGROUND: The present review is aimed to evaluate the correlation between pathological features and the response to steroid in the patients with IgA nephropathy according to the Oxford classification, mesangial hypercellularity (M), endocapillary hypercellularity (E), segmental glomerulosclerosis (S), tubular atrophy and interstitial fibrosis (T).

METHODS: We searched Chinese Biomedical Database, EMBASE, Cochrane Library, PubMed and MEDLINE with all spellings of "IgA nephropathy", "Oxford Classification", and "steroid".

RESULTS: 5 studies with 637 patients were eligible for inclusion. The analysis showed that M1, S1, and T1/2 was strongly associated with the prediction to steroid resistance when compared with M0 [odds ratio (OR) 1.89, 95% confidence interval (

CONCLUSION: IgA nephropathy patients with serious pathological changes (M1, S1, and T1/2) were more resistant to steroid than slight ones (M0, S0, and T0), and E1 is better response to steroid therapy than T1/2.

Keywords: IgA nephropathy; Oxford classification; proteinuria; steroid

Conflict of interest statement

CONFLICTS OF INTEREST The authors have declared that there is no competing interest.

References

  1. Am J Kidney Dis. 1991 Jul;18(1):12-9 - PubMed
  2. Kidney Int. 2012 Oct;82(8):840-56 - PubMed
  3. Nihon Jinzo Gakkai Shi. 1988 Mar;30(3):247-51 - PubMed
  4. Curr Opin Nephrol Hypertens. 2009 May;18(3):212-9 - PubMed
  5. J Nephrol. 2016 Jun;29(3):367-375 - PubMed
  6. Clin J Am Soc Nephrol. 2011 Sep;6(9):2175-84 - PubMed
  7. Nephrol Dial Transplant. 2005 Feb;20(2):342-8 - PubMed
  8. Am J Kidney Dis. 2013 Nov;62(5):891-9 - PubMed
  9. Chin Med J (Engl). 2002 Sep;115(9):1301-7 - PubMed
  10. J Am Soc Nephrol. 2017 Feb;28(2):691-701 - PubMed
  11. Kidney Int. 2009 Sep;76(5):534-45 - PubMed
  12. Oncotarget. 2016 Jun 7;7(23):33616-26 - PubMed
  13. N Engl J Med. 2013 Jun 20;368(25):2402-14 - PubMed
  14. Int Urol Nephrol. 2012 Aug;44(4):1177-84 - PubMed
  15. J Am Soc Nephrol. 2015 Sep;26(9):2248-58 - PubMed
  16. Clin Nephrol. 1986 Oct;26(4):174-80 - PubMed
  17. J Nephrol. 2005 Sep-Oct;18(5):503-12 - PubMed
  18. Clin Nephrol. 2009 Jun;71(6):625-31 - PubMed
  19. J Korean Med Sci. 2009 Jan;24 Suppl:S44-9 - PubMed
  20. Ann Intern Med. 2009 Aug 18;151(4):W65-94 - PubMed
  21. Pediatr Nephrol. 2015 Jul;30(7):1121-9 - PubMed
  22. Kidney Int. 2014 Oct;86(4):828-36 - PubMed
  23. Am J Kidney Dis. 2000 Aug;36(2):227-37 - PubMed
  24. Kidney Int. 2017 May;91(5):1014-1021 - PubMed
  25. Am J Kidney Dis. 2007 Jun;49(6):763-75 - PubMed
  26. Clin Exp Nephrol. 2016 Apr;20(2):244-52 - PubMed
  27. Intern Med. 2015;54(17):2207-11 - PubMed
  28. Q J Med. 1985 Oct;57(222):677-88 - PubMed

Publication Types