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Yfanti C, Tsiokanos A, Fatouros IG, et al. Chronic Eccentric Exercise and Antioxidant Supplementation: Effects on Lipid Profile and Insulin Sensitivity. J Sports Sci Med. 2017;16(3):375-382
Yfanti, C., Tsiokanos, A., Fatouros, I. G., Theodorou, A. A., Deli, C. K., Koutedakis, Y., & Jamurtas, A. Z. (2017). Chronic Eccentric Exercise and Antioxidant Supplementation: Effects on Lipid Profile and Insulin Sensitivity. Journal of sports science & medicine, 16(3), 375-382.
Yfanti, Christina, et al. "Chronic Eccentric Exercise and Antioxidant Supplementation: Effects on Lipid Profile and Insulin Sensitivity." Journal of sports science & medicine vol. 16,3 (2017): 375-382.
Yfanti C, Tsiokanos A, Fatouros IG, Theodorou AA, Deli CK, Koutedakis Y, Jamurtas AZ. Chronic Eccentric Exercise and Antioxidant Supplementation: Effects on Lipid Profile and Insulin Sensitivity. J Sports Sci Med. 2017 Aug 08;16(3):375-382. eCollection 2017 Sep. PMID: 28912655; PMCID: PMC5592289.
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J Sports Sci Med. 2017 Aug 08;16(3):375-382. eCollection 2017 Sep.

Chronic Eccentric Exercise and Antioxidant Supplementation: Effects on Lipid Profile and Insulin Sensitivity.

Journal of sports science & medicine

Christina Yfanti, Athanasios Tsiokanos, Ioannis G Fatouros, Anastasios A Theodorou, Chariklia K Deli, Yiannis Koutedakis, Athanasios Z Jamurtas

Affiliations

  1. School of Physical Education and Sport Science, University of Thessaly, Trikala, Greece.
  2. Institute for Research and Technology of Thessaly (I.RE.TE.TH) at Trikala, Greece, Center for Research and Technology Hellas (CERTH) at Thessaloniki.
  3. School of Sports, Performing Arts and Leisure, University of Wolverhampton, United Kingdom.

PMID: 28912655 PMCID: PMC5592289

Abstract

Eccentric exercise has been shown to exert beneficial effects in both lipid profile and insulin sensitivity. Antioxidant supplementation during chronic exercise is controversial as it may prevent the physiological training-induced adaptations. The aim of this study was to investigate: 1) the minimum duration of the eccentric exercise training required before changes on metabolic parameters are observed and 2) whether antioxidant supplementation during training would interfere with these adaptations. Sixteen young healthy men were randomized into the Vit group (1 g of vitamin C and 400 IU vitamin E daily) and the placebo (PL) group. Subjects received the supplementation for 9 weeks. During weeks 5-9 all participants went through an eccentric exercise training protocol consisting of two exercise sessions (5 sets of 15 eccentric maximal voluntary contractions) per week. Plasma triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), apolipoproteins (Apo A1, Apo B and Lpa) and insulin sensitivity (HOMA) were assessed before the supplementation (week 0), at weeks 5, 6, 7, 8 and 9. TG, TC and LDL were significantly lower compared to pre supplementation at both weeks 8 and 9 (P<0.05) in both groups. HDL was significantly elevated after 4 weeks of training (p < 0.005) in both groups. There was no effect of the antioxidant supplementation in any of the variables. There was no effect of either the training or the supplementation protocol in apolipoproteins levels and insulin sensitivity. A minimum duration of 3 weeks of eccentric exercise training is required before beneficial effects in lipid profile can be observed in healthy young men. Concomitant antioxidant supplementation does not interfere with the training-induced adaptations.

Keywords: Eccentric exercise; insulin sensitivity; metabolic profile; vitamin supplementation

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