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Buckemüller C, Siehler O, Göbel J, et al. Octopamine Underlies the Counter-Regulatory Response to a Glucose Deficit in Honeybees (. Front Syst Neurosci. 2017;11:63doi: 10.3389/fnsys.2017.00063.
Buckemüller, C., Siehler, O., Göbel, J., Zeumer, R., Ölschläger, A., & Eisenhardt, D. (2017). Octopamine Underlies the Counter-Regulatory Response to a Glucose Deficit in Honeybees (. Frontiers in systems neuroscience, 1163. https://doi.org/10.3389/fnsys.2017.00063
Buckemüller, Christina, et al. "Octopamine Underlies the Counter-Regulatory Response to a Glucose Deficit in Honeybees (." Frontiers in systems neuroscience vol. 11 (2017): 63. doi: https://doi.org/10.3389/fnsys.2017.00063
Buckemüller C, Siehler O, Göbel J, Zeumer R, Ölschläger A, Eisenhardt D. Octopamine Underlies the Counter-Regulatory Response to a Glucose Deficit in Honeybees (. Front Syst Neurosci. 2017 Aug 30;11:63. doi: 10.3389/fnsys.2017.00063. eCollection 2017. PMID: 28912693; PMCID: PMC5582081.
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Front Syst Neurosci. 2017 Aug 30;11:63. doi: 10.3389/fnsys.2017.00063. eCollection 2017.

Octopamine Underlies the Counter-Regulatory Response to a Glucose Deficit in Honeybees (.

Frontiers in systems neuroscience

Christina Buckemüller, Oliver Siehler, Josefine Göbel, Richard Zeumer, Anja Ölschläger, Dorothea Eisenhardt

Affiliations

  1. Neurobiologie, Institut für Biologie, Fachbereich Biologie, Chemie, Pharmazie, Freie Universität BerlinBerlin, Germany.

PMID: 28912693 PMCID: PMC5582081 DOI: 10.3389/fnsys.2017.00063

Abstract

An animal's internal state is a critical parameter required for adaptation to a given environment. An important aspect of an animal's internal state is the energy state that is adjusted to the needs of an animal by energy homeostasis. Glucose is one essential source of energy, especially for the brain. A shortage of glucose therefore triggers a complex response to restore the animal's glucose supply. This counter-regulatory response to a glucose deficit includes metabolic responses like the mobilization of glucose from internal glucose stores and behavioral responses like increased foraging and a rapid intake of food. In mammals, the catecholamines adrenalin and noradrenalin take part in mediating these counter-regulatory responses to a glucose deficit. One candidate molecule that might play a role in these processes in insects is octopamine (OA). It is an invertebrate biogenic amine and has been suggested to derive from an ancestral pathway shared with adrenalin and noradrenalin. Thus, it could be hypothesized that OA plays a role in the insect's counter-regulatory response to a glucose deficit. Here we tested this hypothesis in the honeybee (

Keywords: PER; feeding state; glucose deficit; hemolymph; honeybee; hunger; octopamine; survival

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