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Gozali P, Boonsiriseth K, Kiattavornchareon S, et al. Decreased post-operative pain using a sublingual injection of dexamethasone (8 mg) in lower third molar surgery. J Dent Anesth Pain Med. 2017;17(1):47-53doi: 10.17245/jdapm.2017.17.1.47.
Gozali, P., Boonsiriseth, K., Kiattavornchareon, S., Khanijou, M., & Wongsirichat, N. (2017). Decreased post-operative pain using a sublingual injection of dexamethasone (8 mg) in lower third molar surgery. Journal of dental anesthesia and pain medicine, 17(1), 47-53. https://doi.org/10.17245/jdapm.2017.17.1.47
Gozali, Peiter, et al. "Decreased post-operative pain using a sublingual injection of dexamethasone (8 mg) in lower third molar surgery." Journal of dental anesthesia and pain medicine vol. 17,1 (2017): 47-53. doi: https://doi.org/10.17245/jdapm.2017.17.1.47
Gozali P, Boonsiriseth K, Kiattavornchareon S, Khanijou M, Wongsirichat N. Decreased post-operative pain using a sublingual injection of dexamethasone (8 mg) in lower third molar surgery. J Dent Anesth Pain Med. 2017 Mar;17(1):47-53. doi: 10.17245/jdapm.2017.17.1.47. Epub 2017 Mar 27. PMID: 28879328; PMCID: PMC5564136.
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J Dent Anesth Pain Med. 2017 Mar;17(1):47-53. doi: 10.17245/jdapm.2017.17.1.47. Epub 2017 Mar 27.

Decreased post-operative pain using a sublingual injection of dexamethasone (8 mg) in lower third molar surgery.

Journal of dental anesthesia and pain medicine

Peiter Gozali, Kiatanant Boonsiriseth, Sirichai Kiattavornchareon, Manop Khanijou, Natthamet Wongsirichat

Affiliations

  1. Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.

PMID: 28879328 PMCID: PMC5564136 DOI: 10.17245/jdapm.2017.17.1.47

Abstract

BACKGROUND: Every patient who undergoes mandibular third molar surgery is concerned about post-operative pain. Indeed, previous researchers have used various methods to treat such pain. This study aimed to assess the effectiveness of sublingual injection of dexamethasone (8 mg) to treat post-operative pain after mandibular third molar surgery.

METHOD: This was a randomized, double-blind, split-mouth, clinical trial, involving 48 healthy patients who required surgical removal of two mandibular third molars with similar bilateral positions. All operations were performed by the same experienced surgeon. The patients were randomized into a study group (8 mg dexamethasone injection) and a placebo group (normal saline injection). Both interventions were injected into the sublingual space immediately after local anesthesia, 30 min before the first incision. The study group received an 8 mg dexamethasone injection, while the placebo group received a normal saline injection. The wash period between the patients' two operations was 3 to 4 weeks. Pain was assessed by recording the number of analgesic tablets (rescue drug) consumed, as well as by noting the patients' responses to the visual analog scale (VAS) on the first, second, and third days after surgery.

RESULTS: The study group differed significantly from the placebo group in terms of VAS score and analgesic consumption.

CONCLUSION: Dexamethasone (8 mg), injected sublingually, significantly eased post-operative pain after surgical removal of the mandibular third molar.

Keywords: Dexamethasone; Pain; Postoperative Pain; Sublingual Administration; Tooth, Impacted; Visual Analog Scale

Conflict of interest statement

NOTES: There are no financial or other issues that might lead to conflict of interest.

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