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Arch Virol. 1997 Jul;142(7):1481-1489. doi: 10.1007/s007050050174.

Genetic Variation in the VP7 Gene of Human Rotavirus Serotype 3 (G3 Type) Isolated in China and Japan.

Archives of virology

L Wen, M Nakayama, Y Yamanishi, O Nishio, Z -Y Fang, O Nakagomi, K Araki, S Nishimura, A Hasegawa, W E G Müller, H Ushijima

Affiliations

  1. Department of Maternal and Child Health, Faculty of Medicine, The University of Tokyo, Tokyo, Japan, Japan.
  2. Kagawa Prefectural Institute of Health, Kagawa, Japan, Japan.
  3. Institute of Public Health, Tokyo, Japan, Japan.
  4. Institute of Virology, Chinese Academy of Preventive Medicine, Beijing China, China.
  5. Department of Microbiology, Akita University School of Medicine, Akita, Japan, Japan.
  6. Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan, Japan.
  7. Maizuru City Hospital, Kvoto, Japan,, Japan.
  8. National Institute of Health, Tokyo, Japan, Japan.
  9. Institute für Physiologische Chemie, Universität Mainz, Mainz, Germany, Germany.

PMID: 28879402 DOI: 10.1007/s007050050174

Abstract

Sequence analysis of the VP7 gene was performed on twenty-one human isolates of serotype 3 related-rotavirus in China and Japan. The five Chinese isolates were found to be not similar to the 16 Japanese isolates and to SAff11 (simian rotavirus). The Chinese isolates, especially CHW2 and CH-32, were different from the major serotype 3 human isolates. AU-1 and 02/92 which previously showed a wider spacing between RNA segments 10 and 11 by RNA polyacrylamide gel electrophoretic analysis, were more closely related to each other and could be differentiated from the other Chinese and Japanese isolates. For these reasons, serotype 3 viruses were considered to be intra-serotypically more heterologous than serotype 1, 2 and 4 viruses.

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