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Zhao H, Zhang J, Gu D, et al. Tirofiban facilitates the reperfusion process during endovascular thrombectomy in ICAS. Exp Ther Med. 2017;14(4):3314-3318doi: 10.3892/etm.2017.4856.
Zhao, H., Zhang, J., Gu, D., Shi, Z., Pan, J., Geng, Y., & Shi, T. (2017). Tirofiban facilitates the reperfusion process during endovascular thrombectomy in ICAS. Experimental and therapeutic medicine, 14(4), 3314-3318. https://doi.org/10.3892/etm.2017.4856
Zhao, Hongchen, et al. "Tirofiban facilitates the reperfusion process during endovascular thrombectomy in ICAS." Experimental and therapeutic medicine vol. 14,4 (2017): 3314-3318. doi: https://doi.org/10.3892/etm.2017.4856
Zhao H, Zhang J, Gu D, Shi Z, Pan J, Geng Y, Shi T. Tirofiban facilitates the reperfusion process during endovascular thrombectomy in ICAS. Exp Ther Med. 2017 Oct;14(4):3314-3318. doi: 10.3892/etm.2017.4856. Epub 2017 Jul 31. PMID: 28912883; PMCID: PMC5585762.
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Exp Ther Med. 2017 Oct;14(4):3314-3318. doi: 10.3892/etm.2017.4856. Epub 2017 Jul 31.

Tirofiban facilitates the reperfusion process during endovascular thrombectomy in ICAS.

Experimental and therapeutic medicine

Hongchen Zhao, Jinhua Zhang, Danyan Gu, Zongjie Shi, Jie Pan, Yu Geng, Tianming Shi

Affiliations

  1. Department of Neurology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China.
  2. Department of Intensive Care Medicine, Xiasha Hospital, Hangzhou, Zhejiang 310018, P.R. China.

PMID: 28912883 PMCID: PMC5585762 DOI: 10.3892/etm.2017.4856

Abstract

The aim of the present study was to assess the use of tirofiban injections for rescue therapy following artery reocclusion due to intra-luminal thrombosis during endovascular thrombectomy in patients with acute ischemic stroke (AIS). A total of seven cases of patients treated with adjunctive tirofiban injections following failed endovascular thrombectomy due to instant intra-luminal thrombosis were retrospectively assessed. A Solitaire stent was used as the primary thrombectomy device in all patients. Tirofiban was injected intra-arterially via a temporarily deployed Solitaire stent with continuous intravenous infusion for the subsequent 24 h; half of the conventionally recommended dose was employed. Outcome measures included angiographic reperfusion (mTICI), symptomatic intracranial hemorrhage, mortality and functional independence at 90 days (modified Rankin Scale, 0-2). Six patients had occlusions in the middle cerebral artery and one patient had occlusions in the basilar artery. Of the seven patients, five exhibited successful reperfusion (mTICI 2b-3) and achieved functional independence following 90 days. Reperfusion failed in the remaining two patients, who succumbed within 90 days of therapy. No intracranial or extracranial hemorrhage cases were identified. The results of the present study suggest that tirofiban facilitates reperfusion and ameliorates long-term prognosis in patients with AIS undergoing endovascular thrombectomy, and may be safe for those receiving intravenous tissue plasminogen activator therapy.

Keywords: acute ischemic stroke; endovascular thrombectomy; intra-luminal thrombosis; tirofiban

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