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Parkinsons Dis. 2017;2017:5015307. doi: 10.1155/2017/5015307. Epub 2017 Aug 21.

Chaperone-Based Therapies for Disease Modification in Parkinson's Disease.

Parkinson's disease

Erik L Friesen, Mitch L De Snoo, Luckshi Rajendran, Lorraine V Kalia, Suneil K Kalia

Affiliations

  1. Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, Canada.
  2. Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, Canada.
  3. Faculty of Medicine, University of British Columbia, 317-2194 Health Sciences Mall, Vancouver, BC, Canada.
  4. Morton and Gloria Shulman Movement Disorders Clinic and The Edmond J. Safra Program in Parkinson's Disease, Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, Canada.
  5. Division of Neurology, Department of Medicine and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 190 Elizabeth Street, Toronto, ON, Canada.
  6. Division of Neurosurgery, Department of Surgery, University of Toronto, 149 College Street, Toronto, ON, Canada.

PMID: 28913005 PMCID: PMC5585656 DOI: 10.1155/2017/5015307

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder and is characterized by the presence of pathological intracellular aggregates primarily composed of misfolded

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