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Yılmaz S, Akdağ Cırık D, Demirtaş C, et al. Do vitamin D and high-sensitivity-C reactive protein levels differ in patients with hyperemesis gravidarum? A preliminary study. Turk J Obstet Gynecol. 2016;13(3):123-126doi: 10.4274/tjod.76753.
Yılmaz, S., Akdağ Cırık, D., Demirtaş, C., Timur, H., Şahin, A., Danışman, N., & Uygur, D. (2016). Do vitamin D and high-sensitivity-C reactive protein levels differ in patients with hyperemesis gravidarum? A preliminary study. Turkish journal of obstetrics and gynecology, 13(3), 123-126. https://doi.org/10.4274/tjod.76753
Yılmaz, Saynur, et al. "Do vitamin D and high-sensitivity-C reactive protein levels differ in patients with hyperemesis gravidarum? A preliminary study." Turkish journal of obstetrics and gynecology vol. 13,3 (2016): 123-126. doi: https://doi.org/10.4274/tjod.76753
Yılmaz S, Akdağ Cırık D, Demirtaş C, Timur H, Şahin A, Danışman N, Uygur D. Do vitamin D and high-sensitivity-C reactive protein levels differ in patients with hyperemesis gravidarum? A preliminary study. Turk J Obstet Gynecol. 2016 Sep;13(3):123-126. doi: 10.4274/tjod.76753. Epub 2016 Sep 15. PMID: 28913106; PMCID: PMC5558301.
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Turk J Obstet Gynecol. 2016 Sep;13(3):123-126. doi: 10.4274/tjod.76753. Epub 2016 Sep 15.

Do vitamin D and high-sensitivity-C reactive protein levels differ in patients with hyperemesis gravidarum? A preliminary study.

Turkish journal of obstetrics and gynecology

Saynur Yılmaz, Derya Akdağ Cırık, Canan Demirtaş, Hakan Timur, Ayşe Şahin, Nuri Danışman, Dilek Uygur

Affiliations

  1. Etlik Zübeyde Han?m Women's Health Training and Research Hospital, Clinic of Obstetrics and Gynecology, Ankara, Turkey.
  2. Gazi University Faculty of Medicine, Department of Biochemistry, Ankara, Turkey.
  3. Zekai Tahir Burak Women's Health Training and Research Hospital, Clinic of Obstetrics and Gynecology, Ankara, Turkey.

PMID: 28913106 PMCID: PMC5558301 DOI: 10.4274/tjod.76753

Abstract

OBJECTIVES: The high sensitivity-C reactive protein (hs-CRP) is an inflammatory marker and vitamin D is an immune modulator that might play a critical role in the pathogenesis of hyperemesis gravidarum. Therefore, in the current study, we tested the hypothesis that suggests women with hyperemesis gravidarum have lower 25-hydroxyvitamin D levels and higher hs-CRP levels, compared to controls.

MATERIALS AND METHODS: This prospective case-control study included 30 women with hyperemesis gravidarum (study group) and 30 age- and body mass index-matched healthy women (control group). The levels of 25-hydroxyvitamin D and hs-CRP were compared between two groups.

RESULTS: Both the serum 25-hydroxyvitamin D (5.30 μg/L vs. 6.44 μg/L; p=0.09) and hs-CRP levels (0.29 mg/dL vs. 0.47 mg/dL; p=0.93) were not significantly different between the study and control groups. Vitamin D deficiency was present in 27 (90.0%) women in the study group and 22 (73.3%) women in the control group (p=0.181). There was also no correlation between 25-hydroxyvitamin D and hs-CRP levels in both groups.

CONCLUSION: Although it did not reach statistical significance, vitamin D levels were lower in the study group compared with controls. Therefore, vitamin D might be speculated to play a crucial role in controlling the inflammatory status associated with hyperemesis gravidarum. Larger studies are required to clarify whether there is a relation between vitamin D deficiency and hyperemesis gravidarum.

Keywords: C-reactive protein; Vitamin D; hyperemesis gravidarum; inflammation

Conflict of interest statement

Conflict of Interest: All authors declare no conflict of interest or competing interests.

References

  1. J Endocrinol. 2015 Mar;224(3):R107-21 - PubMed
  2. Obstet Gynecol. 2003 Apr;101(4):639-44 - PubMed
  3. J Matern Fetal Neonatal Med. 2013 Jun;26(9):889-99 - PubMed
  4. Hum Reprod. 2014 Feb;29(2):208-19 - PubMed
  5. Int J Gynaecol Obstet. 2002 Nov;79(2):105-9 - PubMed
  6. Am J Obstet Gynecol. 2014 Aug;211(2):150.e1-15 - PubMed
  7. Infect Dis Obstet Gynecol. 1999;7(4):195-8 - PubMed
  8. Gastroenterol Clin North Am. 2011 Jun;40(2):309-34, vii - PubMed
  9. Am J Obstet Gynecol. 2002 Dec;187(6):1631-5 - PubMed
  10. Clin Chem. 2003 Oct;49(10):1667-9 - PubMed
  11. Circulation. 2003 Jan 28;107(3):499-511 - PubMed
  12. Arch Gynecol Obstet. 2003 Nov;269(1):13-5 - PubMed
  13. Gynecol Obstet Invest. 1999;47(4):229-34 - PubMed
  14. Intensive Care Med. 2006 Sep;32(9):1344-51 - PubMed
  15. Am J Clin Nutr. 2015 Sep;102(3):633-8 - PubMed
  16. Ann Nutr Metab. 2013;63(4):331-40 - PubMed
  17. Am J Obstet Gynecol. 2005 Sep;193(3 Pt 1):811-4 - PubMed
  18. BMC Pregnancy Childbirth. 2009 Jul 02;9:26 - PubMed
  19. Eur J Cardiovasc Prev Rehabil. 2005 Feb;12(1):68-74 - PubMed
  20. Eur Rev Med Pharmacol Sci. 2013 Jan;17(1):138-40 - PubMed

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