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Erkan G, Tayyar AT, Açmaz G, et al. Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance. Turk J Obstet Gynecol. 2017;14(2):89-93doi: 10.4274/tjod.61224.
Erkan, G., Tayyar, A. T., Açmaz, G., Müderris, �. �. �. �., Başkol, G., & Bayram, F. (2017). Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance. Turkish journal of obstetrics and gynecology, 14(2), 89-93. https://doi.org/10.4274/tjod.61224
Erkan, Gönül, et al. "Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance." Turkish journal of obstetrics and gynecology vol. 14,2 (2017): 89-93. doi: https://doi.org/10.4274/tjod.61224
Erkan G, Tayyar AT, Açmaz G, Müderris İİ, Başkol G, Bayram F. Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance. Turk J Obstet Gynecol. 2017 Jun;14(2):89-93. doi: 10.4274/tjod.61224. Epub 2017 Jun 15. PMID: 28913143; PMCID: PMC5558419.
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Turk J Obstet Gynecol. 2017 Jun;14(2):89-93. doi: 10.4274/tjod.61224. Epub 2017 Jun 15.

Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance.

Turkish journal of obstetrics and gynecology

Gönül Erkan, Ahter Tanay Tayyar, Gökhan Açmaz, İptisam İpek Müderris, Gülden Başkol, Fahri Bayram

Affiliations

  1. Private Hüma Hospital, Clinic of Obstetrics and Gynecology, Kayseri, Turkey.
  2. Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, Clinic of Obstetrics and Gynecology, ?stanbul, Turkey.
  3. Kayseri Training and Research Hospital, Clinic of Obstetrics and Gynecology, Kayseri, Turkey.
  4. Erciyes University Faculty of Medicine, Department of Obstetrics and Gynecology, Kayseri, Turkey.
  5. Erciyes University Faculty of Medicine, Department of Biochemistry, Kayseri, Turkey.
  6. Erciyes University Faculty of Medicine, Department of Clinical Endocrinology and Metabolism, Kayseri, Turkey.

PMID: 28913143 PMCID: PMC5558419 DOI: 10.4274/tjod.61224

Abstract

OBJECTIVE: Insulin resistance (IR) seems to be the main pathogenic factor in polycystic ovary syndrome (PCOS). Adiponectin and tumor necrosis factor-alpha (TNF-α) are important in IR. The aim of this study was to evaluate the correlations of osteocalcin, adiponectin, and TNF-α with IR in PCOS.

MATERIALS AND METHODS: A total of 60 women were divided into two groups. The first group constituted 44 patients with PCOS and the control group comprised 16 healthy women. Osteocalcin, adiponectin, TNF-α levels, body mass index (BMI), and IR in the fasting state were assessed and correlations of these parameters were evaluated.

RESULTS: Homeostasis model assessment (HOMA)-IR, adiponectin, osteocalcin, and androstenedione levels were significantly increased in the PCOS group. A moderate positive correlation between BMI and HOMA-IR, a moderate negative correlation between TNF-α and osteocalcin, and a mild negative correlation between adiponectin and BMI were detected in PCOS.

CONCLUSION: Osteocalcin may have impact on adiponectin, TNF-α, and IR levels in PCOS. Different osteocalcin levels in patients with PCOS may be responsible for explaining PCOS heterogeneity.

Keywords: Adiponectin; Polycystic ovary syndrome; insulin resistance; osteocalcin; tumor necrosis factor-alpha

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

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