Arch Craniofac Surg. 2017 Jun;18(2):105-111. doi: 10.7181/acfs.2017.18.2.105. Epub 2017 Jun 26.
Metastatic Squamous Cell Carcinoma of the Lower Lip: Analysis of the 5-Year Survival Rate.
Archives of craniofacial surgery
Tommaso Agostini, Giuseppe Spinelli, Francesco Arcuri, Raffaella Perello
Affiliations
Affiliations
- Department of Maxillo-Facial Surgery, CTO-AOUC, University of Florence, Florence, Italy.
- Department of Plastic and Reconstructive Surgery, Centro Chirurgico San Paolo, Pistoia, Italy.
PMID: 28913316
PMCID: PMC5556890 DOI: 10.7181/acfs.2017.18.2.105
Abstract
OBJECTIVES: The author analyse the impact of extracapsular lymph node spread and bone engagement in the ipsilateral neck of patients suffering squamous cell carcinoma (SCC) of the lower lip.
METHODS: The data of 56 neck dissections performed in patients suffering SCC of the lower lip between January 2000 and December 2008 were retrospectively analysed. Statistical analysis was performed with the Kaplan-Meier life table method, and the survival rate was investigated with the log rank statistic and significance test. The values were considered statistically significant at
RESULTS: Nine patients took advantage from simultaneous treatment of tumor and prophylactic neck dissection (level I-III), reaching 100% survival rate. Patients suffering metastasized disease, who received radical neck dissection at the time of tumor treatment, presented 83.3% survival rate. Patients who underwent previous surgery and radiotherapy presented worse prognosis although radical neck dissection in case of extra-capsular spread only (24.7%) and osseous engagement (22.2%).
CONCLUSION: Prophylactic neck dissection (level I-III) is recommended in T3-T4 N0 SCC. Simultaneous treatment of tumor and cervical lymph nodes provides a better prognosis as respect to delayed nodal management. Extra-capsular spread with or without bone engagement represents independent risk factor responsible for high mortality rate of SCC of the lower lip.
Keywords: Lip; Neck dissection; Squamous cell carcinoma
References
- Head Neck. 2002 Jul;24(7):678-83 - PubMed
- J Craniofac Surg. 2007 Sep;18(5):1079-82 - PubMed
- Ann Plast Surg. 2003 Jan;50(1):43-50 - PubMed
- J Oral Maxillofac Surg. 2007 Apr;65(4):675-9 - PubMed
- J Craniomaxillofac Surg. 1995 Jun;23 (3):155-9 - PubMed
- J Craniomaxillofac Surg. 2004 Feb;32(1):16-8 - PubMed
- J Craniomaxillofac Surg. 2010 Jun;38(4):260-5 - PubMed
- Acta Chir Belg. 2003 Jun;103(3):304-8 - PubMed
- J Plast Surg Hand Surg. 2013 Jun;47(3):204-8 - PubMed
- J Craniomaxillofac Surg. 1995 Feb;23(1):34-7 - PubMed
- Otolaryngol Head Neck Surg. 1995 Nov;113(5):589-96 - PubMed
- Pathol Res Pract. 1998;194(5):319-24 - PubMed
- Kulak Burun Bogaz Ihtis Derg. 2002 Jan-Feb;9(1):41-5 - PubMed
- Ann Otol Rhinol Laryngol. 1997 Sep;106(9):787-9 - PubMed
- Oral Oncol. 2004 Jan;40(1):92-8 - PubMed
- Otolaryngol Head Neck Surg. 2000 Jan;122(1):139-42 - PubMed
- Onkologie. 2004 Aug;27(4):363-7 - PubMed
- Coll Antropol. 2008 Oct;32 Suppl 2:199-202 - PubMed
- Head Neck. 1999 Sep;21(6):526-30 - PubMed
- Otolaryngol Head Neck Surg. 2004 Oct;131(4):503-8 - PubMed
- J Oral Maxillofac Surg. 1998 Jul;56(7):814-20; discussion 820-1 - PubMed
- Australas Radiol. 2001 May;45(2):195-9 - PubMed
- Eur Arch Otorhinolaryngol. 1993;250(8):446-9 - PubMed
- J Exp Clin Cancer Res. 2002 Mar;21(1):29-30 - PubMed
- Stomatologija. 2005;7(3):95-8 - PubMed
Publication Types