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Le Z, Niu X, Chen Y, et al. Predictive single nucleotide polymorphism markers for acute oral mucositis in patients with nasopharyngeal carcinoma treated with radiotherapy. Oncotarget. 2017;8(38):63026-63037doi: 10.18632/oncotarget.18450.
Le, Z., Niu, X., Chen, Y., Ou, X., Zhao, G., Liu, Q., Tu, W., Hu, C., Kong, L., & Liu, Y. (2017). Predictive single nucleotide polymorphism markers for acute oral mucositis in patients with nasopharyngeal carcinoma treated with radiotherapy. Oncotarget, 8(38), 63026-63037. https://doi.org/10.18632/oncotarget.18450
Le, Ziyu, et al. "Predictive single nucleotide polymorphism markers for acute oral mucositis in patients with nasopharyngeal carcinoma treated with radiotherapy." Oncotarget vol. 8,38 (2017): 63026-63037. doi: https://doi.org/10.18632/oncotarget.18450
Le Z, Niu X, Chen Y, Ou X, Zhao G, Liu Q, Tu W, Hu C, Kong L, Liu Y. Predictive single nucleotide polymorphism markers for acute oral mucositis in patients with nasopharyngeal carcinoma treated with radiotherapy. Oncotarget. 2017 Jun 13;8(38):63026-63037. doi: 10.18632/oncotarget.18450. eCollection 2017 Sep 08. PMID: 28968968; PMCID: PMC5609900.
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Oncotarget. 2017 Jun 13;8(38):63026-63037. doi: 10.18632/oncotarget.18450. eCollection 2017 Sep 08.

Predictive single nucleotide polymorphism markers for acute oral mucositis in patients with nasopharyngeal carcinoma treated with radiotherapy.

Oncotarget

Ziyu Le, Xiaoshuang Niu, Ying Chen, Xiaomin Ou, Guoqi Zhao, Qi Liu, Wenzhi Tu, Chaosu Hu, Lin Kong, Yong Liu

Affiliations

  1. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, P. R. China.
  2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P. R. China.
  3. Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 201620, P. R. China.
  4. Cancer Research Institute, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, P. R. China.

PMID: 28968968 PMCID: PMC5609900 DOI: 10.18632/oncotarget.18450

Abstract

The aim of this study was to investigate the association between the susceptibility of severe oral mucositis (OM) in Chinese nasopharyngeal carcinoma (NPC) patients treated with radiotherapy and single nucleotide polymorphisms (SNPs) across the whole genome. SNPs were screened in a total of 24 patients with NPC and an additional 6 were subjected to mRNA expression analysis. Patients were subdivided into CTC 0-2 (CTC toxicity grade 0, 1, and 2) and CTC 3+ (CTC toxicity grade 3 and above) groups according to their CTC (common toxicity criteria) scores. The GTEx dataset was used to performed eQTL analyses and

Keywords: ZNF24; genetic polymorphism; nasopharyngeal carcinoma; oral mucositis; radiotherapy

Conflict of interest statement

CONFLICTS OF INTEREST There are no conflicts of interest to declare.

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