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Bajpai V, Gupta E, Kundu N, et al. Hepatitis B Core Antibody Negativity in a Chronic Hepatitis B Infected Patient: Report of an Unusual Serological Pattern. J Clin Diagn Res. 2017;11(8):DD04-DD06doi: 10.7860/JCDR/2017/26821.10498.
Bajpai, V., Gupta, E., Kundu, N., Sharma, S., & Shashtry, S. M. (2017). Hepatitis B Core Antibody Negativity in a Chronic Hepatitis B Infected Patient: Report of an Unusual Serological Pattern. Journal of clinical and diagnostic research : JCDR, 11(8), DD04-DD06. https://doi.org/10.7860/JCDR/2017/26821.10498
Bajpai, Vijeta, et al. "Hepatitis B Core Antibody Negativity in a Chronic Hepatitis B Infected Patient: Report of an Unusual Serological Pattern." Journal of clinical and diagnostic research : JCDR vol. 11,8 (2017): DD04-DD06. doi: https://doi.org/10.7860/JCDR/2017/26821.10498
Bajpai V, Gupta E, Kundu N, Sharma S, Shashtry SM. Hepatitis B Core Antibody Negativity in a Chronic Hepatitis B Infected Patient: Report of an Unusual Serological Pattern. J Clin Diagn Res. 2017 Aug;11(8):DD04-DD06. doi: 10.7860/JCDR/2017/26821.10498. Epub 2017 Aug 01. PMID: 28969126; PMCID: PMC5620766.
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J Clin Diagn Res. 2017 Aug;11(8):DD04-DD06. doi: 10.7860/JCDR/2017/26821.10498. Epub 2017 Aug 01.

Hepatitis B Core Antibody Negativity in a Chronic Hepatitis B Infected Patient: Report of an Unusual Serological Pattern.

Journal of clinical and diagnostic research : JCDR

Vijeta Bajpai, Ekta Gupta, Naveen Kundu, Shvetank Sharma, S M Shashtry

Affiliations

  1. Senior Resident, Department of Clinical Virology, Institute of Liver and Biliary Sciences, New Delhi, India.
  2. Additional Professor, Department of Clinical Virology, Institute of Liver and Biliary Sciences, New Delhi, India.
  3. Assistant Professor, Department of Clinical Research, Institute of Liver and Biliary Sciences, New Delhi, India.
  4. Assistant Professor, Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

PMID: 28969126 PMCID: PMC5620766 DOI: 10.7860/JCDR/2017/26821.10498

Abstract

Diagnosis of Hepatitis B Virus (HBV) infection is established by the presence of various hepatitis B serological and molecular markers. Expression of these serological markers may vary in natural course of HBV infection. We report a case of an unusual HBV serological pattern in a Chronic Hepatitis B (CHB) infected patient demonstrating absence of Hepatitis B core Antibody (Anti-HBc) in spite of presence of Hepatitis B surface Antigen (HBsAg) and HBV DNA. Since, anti-HBc represents a reliable serological marker for past exposure of HBV infection, therefore we emphasize on the presence of such unusual serological pattern which could lead to doubts in the interpretation of results.

Keywords: Atypical serology; Diagnostic escape; Hepatitis B core antigen; Hepatitis B virus; Immunotolerance

References

  1. Hepatology. 2009 May;49(5 Suppl):S13-21 - PubMed
  2. J Viral Hepat. 2010 Dec;17(12):887-95 - PubMed
  3. J Virol. 2001 Jul;75(14):6359-66 - PubMed
  4. J Virol. 2005 Mar;79(5):3016-27 - PubMed
  5. Can J Infect Dis Med Microbiol. 2005 Mar;16(2):65-72 - PubMed
  6. J Clin Microbiol. 2006 Jun;44(6):2250-3 - PubMed
  7. World J Gastroenterol. 2016 May 7;22(17 ):4287-96 - PubMed
  8. Blood Transfus. 2014 Jan;12 Suppl 1:s63-8 - PubMed
  9. Eur J Clin Microbiol Infect Dis. 2013 Apr;32(4):461-76 - PubMed
  10. Virol J. 2015 Jun 11;12:87 - PubMed

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