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Jagtap SV, Aher V, Gadhiya S, et al. Gestational Trophoblastic Disease - Clinicopathological Study at Tertiary Care Hospital. J Clin Diagn Res. 2017;11(8):EC27-EC30doi: 10.7860/JCDR/2017/27232.10458.
Jagtap, S. V., Aher, V., Gadhiya, S., & Jagtap, S. S. (2017). Gestational Trophoblastic Disease - Clinicopathological Study at Tertiary Care Hospital. Journal of clinical and diagnostic research : JCDR, 11(8), EC27-EC30. https://doi.org/10.7860/JCDR/2017/27232.10458
Jagtap, Sunil Vitthalrao, et al. "Gestational Trophoblastic Disease - Clinicopathological Study at Tertiary Care Hospital." Journal of clinical and diagnostic research : JCDR vol. 11,8 (2017): EC27-EC30. doi: https://doi.org/10.7860/JCDR/2017/27232.10458
Jagtap SV, Aher V, Gadhiya S, Jagtap SS. Gestational Trophoblastic Disease - Clinicopathological Study at Tertiary Care Hospital. J Clin Diagn Res. 2017 Aug;11(8):EC27-EC30. doi: 10.7860/JCDR/2017/27232.10458. Epub 2017 Aug 01. PMID: 28969138; PMCID: PMC5620778.
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J Clin Diagn Res. 2017 Aug;11(8):EC27-EC30. doi: 10.7860/JCDR/2017/27232.10458. Epub 2017 Aug 01.

Gestational Trophoblastic Disease - Clinicopathological Study at Tertiary Care Hospital.

Journal of clinical and diagnostic research : JCDR

Sunil Vitthalrao Jagtap, Vidhya Aher, Suchi Gadhiya, Swati Sunil Jagtap

Affiliations

  1. Professor, Department of Pathology, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra India.
  2. Assistant Lecturer, Department of Pathology, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra, India.
  3. Associate Professor, Department of Physiology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India.

PMID: 28969138 PMCID: PMC5620778 DOI: 10.7860/JCDR/2017/27232.10458

Abstract

INTRODUCTION: Gestational Trophoblastic Disease (GTD) is a term used for a group of pregnancy-related tumours. These consist of various tumours and tumour like lesions characterized by proliferation of trophoblastic tissue. Amongst GTD, hydatidiform moles are the most common form. These lesions sometimes may develop into invasive moles, or, in rare cases, into choriocarcinoma.

AIM: To study the clinicopathologic characteristics and prevalence of different forms of gestational trophoblastic disease in a tertiary care hospital.

MATERIALS AND METHODS: The present study was descriptive, observational, analytical type done in Department of Pathology at tertiary care hospital from May 2012 to April 2016. All cases clinically suspected of GTD were included and confirmation was done by histopathological study on H&E stained slides. The cases of GTD were classified according to WHO classification. Detailed histomorphological features and beta human Chorionic Gonadotropin (hCG) levels were correlated.

RESULTS: During study period, 18345 deliveries were reported; out of which 77 cases were diagnosed as GTD. Almost 97.40% cases were of hydatidiform moles, 1.30% cases of choriocarcinoma and 1.30% cases of Placental Site Trophoblastic Tumour (PSTT). Among the cases of hydatidiform mole 57.34% were complete mole and 41.33% cases were of partial mole. The common clinical presentation was per vaginal bleeding and amenorrhea. The blood group A was most commonly observed in patient (49.35%). In majority of cases beta hCG levels were between 50,000 to 100000 mIU/ml. The correlation between beta hCG level and GTD were done.

CONCLUSION: Pregnant females clinically presenting with abnormal vaginal bleeding must be evaluated for GTD. Histopathological examination is helpful for confirmatory diagnosis. Follow up of such patients is essential for early detection of malignant trophoblastic tumours.

Keywords: Disorders; Hydatid mole; Pregnancy

References

  1. Clin Obstet Gynecol. 2003 Sep;46(3):541-56 - PubMed
  2. Med Sci Monit. 2003 Oct;9(10):CR442-7 - PubMed
  3. Int J Gynaecol Obstet. 2003 Nov;83(2):179-86 - PubMed
  4. Zhonghua Fu Chan Ke Za Zhi. 2005 Feb;40(2):76-8 - PubMed
  5. Indian J Pathol Microbiol. 2009 Jul-Sep;52(3):417-20 - PubMed
  6. Lancet. 2010 Aug 28;376(9742):717-29 - PubMed
  7. Am J Obstet Gynecol. 2010 Dec;203(6):531-9 - PubMed
  8. Int J Gynecol Pathol. 2011 Mar;30(2):101-16 - PubMed
  9. Br J Cancer. 2011 May 24;104(11):1665-9 - PubMed
  10. ISRN Obstet Gynecol. 2011;2011:925316 - PubMed
  11. Kathmandu Univ Med J (KUMJ). 2011 Oct-Dec;9(36):298-300 - PubMed
  12. Gynecol Oncol Res Pract. 2015 Oct 31;2:9 - PubMed
  13. Tumori. 1985 Apr 30;71(2):123-6 - PubMed
  14. Am J Epidemiol. 1986 Jun;123(6):1094-100 - PubMed
  15. Adv Exp Med Biol. 1984;176:165-75 - PubMed
  16. J Reprod Med. 1994 Mar;39(3):155-62 - PubMed

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