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Byeon JH, Ri S, Amarsaikhan O, et al. Association Between Sensitization to Mold and Impaired Pulmonary Function in Children With Asthma. Allergy Asthma Immunol Res. 2017;9(6):509-516doi: 10.4168/aair.2017.9.6.509.
Byeon, J. H., Ri, S., Amarsaikhan, O., Kim, E., Ahn, S. H., Choi, I. S., Kim, H. J., Seo, S., Yoon, W., & Yoo, Y. (2017). Association Between Sensitization to Mold and Impaired Pulmonary Function in Children With Asthma. Allergy, asthma & immunology research, 9(6), 509-516. https://doi.org/10.4168/aair.2017.9.6.509
Byeon, Jung Hye, et al. "Association Between Sensitization to Mold and Impaired Pulmonary Function in Children With Asthma." Allergy, asthma & immunology research vol. 9,6 (2017): 509-516. doi: https://doi.org/10.4168/aair.2017.9.6.509
Byeon JH, Ri S, Amarsaikhan O, Kim E, Ahn SH, Choi IS, Kim HJ, Seo S, Yoon W, Yoo Y. Association Between Sensitization to Mold and Impaired Pulmonary Function in Children With Asthma. Allergy Asthma Immunol Res. 2017 Nov;9(6):509-516. doi: 10.4168/aair.2017.9.6.509. PMID: 28913990; PMCID: PMC5603479.
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Allergy Asthma Immunol Res. 2017 Nov;9(6):509-516. doi: 10.4168/aair.2017.9.6.509.

Association Between Sensitization to Mold and Impaired Pulmonary Function in Children With Asthma.

Allergy, asthma & immunology research

Jung Hye Byeon, Soohyun Ri, Oyuntulga Amarsaikhan, Eunji Kim, So Hyun Ahn, Ic Sun Choi, Hyung Jin Kim, SungChul Seo, Wonsuck Yoon, Young Yoo

Affiliations

  1. Department of Pediatrics, Korea University College of Medicine, Anam Hospital, Seoul, Korea.
  2. Allergy Immunology Center, Korea University College of Medicine, Anam Hospital, Seoul, Korea.
  3. Environmental Health Center, Korea University College of Medicine, Anam Hospital, Seoul, Korea.
  4. Allergy Immunology Center, Korea University College of Medicine, Anam Hospital, Seoul, Korea. [email protected].
  5. Environmental Health Center, Korea University College of Medicine, Anam Hospital, Seoul, Korea. [email protected].

PMID: 28913990 PMCID: PMC5603479 DOI: 10.4168/aair.2017.9.6.509

Abstract

PURPOSE: Recent data indicate that sensitization to mold contributes to the severity and persistence of asthma. In this study, we investigated the relationships between sensitization to mold and lung function parameters in children with asthma.

METHODS: We retrospectively reviewed clinical data from 551 asthmatic subjects. We selected subjects who met clinical diagnostic criteria of asthma. Their spirometry, methacholine challenge tests, and measurements of blood eosinophils, serum IgE, eosinophil cationic protein (ECP) and fractional exhaled nitric oxide (FeNO) results were included. Skin prick testing (SPT) results with 13 common aeroallergens in Korea including house dust mites, animal dander, pollen, cockroach and mold were reviewed. Subjects were divided into 3 groups according to their SPT results. Subjects who showed no positive result to any aeroallergen were designated as group 1 (non-sensitized). Group 2 represented subjects who were sensitized to aeroallergens other than mold (other allergen-sensitized) and group 3 included subjects who were sensitized to mold allergens (mold-sensitized).

RESULTS: Among the 551 asthmatic subjects, 67 (12.2%) were sensitized to mold and 366 (66.4%) were sensitized to other aeroallergens. The log mean IgE levels were higher in groups 2 (5.96±1.14 IU/mL) and 3 (5.81±0.97 IU/mL) compared to group 1 (3.88±1.68 IU/mL). Blood eosinophils, ECP and FeNO concentrations were significantly higher in groups 2 and 3, but no significant difference was found between the 2 groups. The mean FEV1 value was significantly lower in group 3 (86.9±12.1%pred) than in groups 2 (92.0±14.8%pred) and 1 (93.4±15.4%pred). The log mean methacholine PC20 was significantly lower in group 3 (0.08±1.91 mg/mL) than in groups 2 (1.31±1.69 mg/mL) and 1 (2.29±1.66 mg/mL).

CONCLUSIONS: We observed a differential association between mold and other aeroallergen sensitization, and severity of asthma. Sensitization to mold is associated with lower lung function and increased airway hyper-responsiveness in children with asthma. Mold sensitization could be an important factor determining asthma severity particularly airflow limitation in children.

Copyright © 2017 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease

Keywords: Asthma; mold; severity

Conflict of interest statement

There are no financial or other issues that might lead to conflict of interest.

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