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Choudhary NS, Bodh V, Chaudhari S, et al. Norethisterone Related Drug Induced Liver Injury: A Series of 3 Cases. J Clin Exp Hepatol. 2017;7(3):266-268doi: 10.1016/j.jceh.2017.01.001.
Choudhary, N. S., Bodh, V., Chaudhari, S., Saraf, N., & Saigal, S. (2017). Norethisterone Related Drug Induced Liver Injury: A Series of 3 Cases. Journal of clinical and experimental hepatology, 7(3), 266-268. https://doi.org/10.1016/j.jceh.2017.01.001
Choudhary, Narendra S, et al. "Norethisterone Related Drug Induced Liver Injury: A Series of 3 Cases." Journal of clinical and experimental hepatology vol. 7,3 (2017): 266-268. doi: https://doi.org/10.1016/j.jceh.2017.01.001
Choudhary NS, Bodh V, Chaudhari S, Saraf N, Saigal S. Norethisterone Related Drug Induced Liver Injury: A Series of 3 Cases. J Clin Exp Hepatol. 2017 Sep;7(3):266-268. doi: 10.1016/j.jceh.2017.01.001. Epub 2017 Apr 21. PMID: 28970715; PMCID: PMC5620103.
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J Clin Exp Hepatol. 2017 Sep;7(3):266-268. doi: 10.1016/j.jceh.2017.01.001. Epub 2017 Apr 21.

Norethisterone Related Drug Induced Liver Injury: A Series of 3 Cases.

Journal of clinical and experimental hepatology

Narendra S Choudhary, Vijay Bodh, Shraddha Chaudhari, Neeraj Saraf, Sanjiv Saigal

Affiliations

  1. Medanta Liver Institute, Medanta, The Medicity, Gurgaon, Haryana, India.
  2. Fortis Hospital, Kangra, Himachal Pradesh, India.
  3. Department of Gynaecology & Gynaeconcology, Medanta, The Medicity, Gurgaon, Haryana, India.

PMID: 28970715 PMCID: PMC5620103 DOI: 10.1016/j.jceh.2017.01.001

Abstract

Drug induced liver injury (DILI) is uncommon and severe forms are associated with significant morbidity and mortality. Female sex hormones (estrogens and progestogens) related DILI generally occur with estrogen component. Progesterone component related DILI are infrequently reported. Norethisterone is commonly used drug in gynecologic practice to prevent excess per vaginal bleeding. We report 3 cases of Norethisterone related DILI manifesting as significant rise of transaminases. All of these patients took Norethisterone for prolonged periods and improved completely after withdrawal of drug.

Keywords: ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; DILI, drug induced liver injury; Norethisterone; ULN, upper limit of normal; drug induced liver injury; progestogens; sex hormones

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