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Zaman JAB, Baykaner T, Schricker AA, et al. Mechanistic targets for the ablation of atrial fibrillation. Glob Cardiol Sci Pract. 2017;2017(1):e201707doi: 10.21542/gcsp.2017.7.
Zaman, J. A. B., Baykaner, T., Schricker, A. A., Krummen, D. E., & Narayan, S. M. (2017). Mechanistic targets for the ablation of atrial fibrillation. Global cardiology science & practice, 2017(1), e201707. https://doi.org/10.21542/gcsp.2017.7
Zaman, Junaid A B, et al. "Mechanistic targets for the ablation of atrial fibrillation." Global cardiology science & practice vol. 2017,1 (2017): e201707. doi: https://doi.org/10.21542/gcsp.2017.7
Zaman JAB, Baykaner T, Schricker AA, Krummen DE, Narayan SM. Mechanistic targets for the ablation of atrial fibrillation. Glob Cardiol Sci Pract. 2017 Mar 31;2017(1):e201707. doi: 10.21542/gcsp.2017.7. PMID: 28971106; PMCID: PMC5621726.
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Glob Cardiol Sci Pract. 2017 Mar 31;2017(1):e201707. doi: 10.21542/gcsp.2017.7.

Mechanistic targets for the ablation of atrial fibrillation.

Global cardiology science & practice

Junaid A B Zaman, Tina Baykaner, Amir A Schricker, David E Krummen, Sanjiv M Narayan

Affiliations

  1. Stanford University, Palo Alto, California.
  2. Imperial College, University of London, United Kingdom.
  3. University of California, San Diego, California.

PMID: 28971106 PMCID: PMC5621726 DOI: 10.21542/gcsp.2017.7

Abstract

The mechanisms responsible for sustaining atrial fibrillation are a key debate in cardiovascular pathophysiology, and directly influence the approach to therapy including ablation Clinical and basic studies have split AF mechanisms into two basic camps: 'spatially distributed disorganization' and 'localized sources'. Recent data suggest that these mechanisms can also be separated by the method for mapping - with nearly all traditional electrogram analyses showing spatially distributed disorganization and nearly all optical mapping studies showing localized sources We will review this dichotomy in light of these recently identified differences in mapping, and in the context of recent clinical studies in which localized ablation has been shown to impact AF, also lending support to the localized source hypothesis. We will conclude with other concepts on mechanism-based ablation and areas of ongoing research that must be addressed to continue improving our knowledge and treatment of AF.

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