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Tward DJ, Sicat CS, Brown T, et al. Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry. Alzheimers Dement (Amst). 2017;9:41-50doi: 10.1016/j.dadm.2017.07.005.
Tward, D. J., Sicat, C. S., Brown, T., Bakker, A., Gallagher, M., Albert, M., & Miller, M. (2017). Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry. Alzheimer's & dementia (Amsterdam, Netherlands), 941-50. https://doi.org/10.1016/j.dadm.2017.07.005
Tward, Daniel J, et al. "Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 9 (2017): 41-50. doi: https://doi.org/10.1016/j.dadm.2017.07.005
Tward DJ, Sicat CS, Brown T, Bakker A, Gallagher M, Albert M, Miller M. Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry. Alzheimers Dement (Amst). 2017 Sep 14;9:41-50. doi: 10.1016/j.dadm.2017.07.005. eCollection 2017. PMID: 28971142; PMCID: PMC5608074.
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Alzheimers Dement (Amst). 2017 Sep 14;9:41-50. doi: 10.1016/j.dadm.2017.07.005. eCollection 2017.

Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry.

Alzheimer's & dementia (Amsterdam, Netherlands)

Daniel J Tward, Chelsea S Sicat, Timothy Brown, Arnold Bakker, Michela Gallagher, Marilyn Albert, Michael Miller

Affiliations

  1. Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA.
  2. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
  3. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
  4. Department of Psychological and Brain Sciences, Johns Hopkins School of Arts and Sciences, Baltimore, MD, USA.
  5. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  6. Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.

PMID: 28971142 PMCID: PMC5608074 DOI: 10.1016/j.dadm.2017.07.005

Abstract

INTRODUCTION: Autopsy findings have shown the entorhinal cortex and transentorhinal cortex are among the earliest sites of accumulation of pathology in patients developing Alzheimer's disease.

METHODS: Here, we study this region in subjects with mild cognitive impairment (

RESULTS: We find significant thickness and volume changes localized to the transentorhinal cortex through high field strength atlasing.

DISCUSSION: This demonstrates that in vivo neuroimaging biomarkers can detect these early changes among subjects with mild cognitive impairment.

Keywords: Braak staging; Diffeomorphometry; Entorhinal cortex; Longitudinal analysis; Mild cognitive impairment; Shape analysis

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