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NPJ Biofilms Microbiomes. 2017 Sep 04;3:19. doi: 10.1038/s41522-017-0027-0. eCollection 2017.

Redox-active conducting polymers modulate .

NPJ biofilms and microbiomes

Salvador Gomez-Carretero, Ben Libberton, Mikael Rhen, Agneta Richter-Dahlfors

Affiliations

  1. Department of Neuroscience, Swedish Medical Nanoscience Center, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
  2. Department of Microbiology, Tumor and Cell biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

PMID: 28883986 PMCID: PMC5583241 DOI: 10.1038/s41522-017-0027-0

Abstract

Biofouling is a major problem caused by bacteria colonizing abiotic surfaces, such as medical devices. Biofilms are formed as the bacterial metabolism adapts to an attached growth state. We studied whether bacterial metabolism, hence biofilm formation, can be modulated in electrochemically active surfaces using the conducting conjugated polymer poly(3,4-ethylenedioxythiophene) (PEDOT). We fabricated composites of PEDOT doped with either heparin, dodecyl benzene sulfonate or chloride, and identified the fabrication parameters so that the electrochemical redox state is the main distinct factor influencing biofilm growth. PEDOT surfaces fitted into a custom-designed culturing device allowed for redox switching in

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