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Wood PL, Siljander H, Knip M. Lipidomics of human umbilical cord serum: identification of unique sterol sulfates. Future Sci OA. 2017;3(3):FSO193doi: 10.4155/fsoa-2017-0012.
Wood, P. L., Siljander, H., & Knip, M. (2017). Lipidomics of human umbilical cord serum: identification of unique sterol sulfates. Future science OA, 3(3), FSO193. https://doi.org/10.4155/fsoa-2017-0012
Wood, Paul L, et al. "Lipidomics of human umbilical cord serum: identification of unique sterol sulfates." Future science OA vol. 3,3 (2017): FSO193. doi: https://doi.org/10.4155/fsoa-2017-0012
Wood PL, Siljander H, Knip M. Lipidomics of human umbilical cord serum: identification of unique sterol sulfates. Future Sci OA. 2017 Apr 05;3(3):FSO193. doi: 10.4155/fsoa-2017-0012. eCollection 2017 Aug. PMID: 28883994; PMCID: PMC5583693.
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Future Sci OA. 2017 Apr 05;3(3):FSO193. doi: 10.4155/fsoa-2017-0012. eCollection 2017 Aug.

Lipidomics of human umbilical cord serum: identification of unique sterol sulfates.

Future science OA

Paul L Wood, Heli Siljander, Mikael Knip

Affiliations

  1. Metabolomics Unit, Department of Physiology & Pharmacology, DeBusk College of Osteopathic Medicine, TN, USA.
  2. College of Veterinary Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy., Harrogate, TN 37752, USA.
  3. Children's Hospital, University of Helsinki & Helsinki University Hospital, Helsinki, Finland.
  4. Research Programs Unit, Diabetes & Obesity, University of Helsinki, Helsinki, Finland.
  5. Folkhälsan Research Center, University of Helsinki, Helsinki, Finland.
  6. Department of Pediatrics, Tampere University Hospital, Tampere, Finland.

PMID: 28883994 PMCID: PMC5583693 DOI: 10.4155/fsoa-2017-0012

Abstract

AIM: There are currently limited lipidomics data for human umbilical cord blood. Therefore, the lipidomes of cord sera from six newborns and sera from six nonpregnant females were compared.

MATERIALS & METHODS: Sera lipidomics analyses were conducted using a high-resolution mass spectrometry analytical platform.

RESULTS: Cord serum contained a diverse array of glycerophospholipids, albeit generally at lower concentrations than monitored in adult serum. The unexpected observations were that cord serum contained several neurosteroid sulfates and bile acid sulfates that were not detectable in adult serum.

CONCLUSION: Our data are the first to demonstrate that cord serum contains bile acid sulfates that are synthesized early in the hydroxylase, neutral and acidic pathways of primary bile acid biosynthesis and support previous publications of cord blood perfluoralkyl toxins in newborns.

Keywords: bile acid sulfates; glycerophospholipids; lipidomics; neurosteroid sulfates; perfluoroalkyl toxins; umbilical cord serum

Conflict of interest statement

Financial & competing interests disclosure This work was funded by College of Veterinary Medicine, Lincoln Memorial University, Sigrid Juselius Foundation and Finska Läkaresällskapet. The authors have

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