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Galluzzi L, Diotallevi A, Magnani M. Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites. Future Sci OA. 2017;3(3):FSO198doi: 10.4155/fsoa-2017-0020.
Galluzzi, L., Diotallevi, A., & Magnani, M. (2017). Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites. Future science OA, 3(3), FSO198. https://doi.org/10.4155/fsoa-2017-0020
Galluzzi, Luca, et al. "Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites." Future science OA vol. 3,3 (2017): FSO198. doi: https://doi.org/10.4155/fsoa-2017-0020
Galluzzi L, Diotallevi A, Magnani M. Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites. Future Sci OA. 2017 May 12;3(3):FSO198. doi: 10.4155/fsoa-2017-0020. eCollection 2017 Aug. PMID: 28883998; PMCID: PMC5583660.
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Future Sci OA. 2017 May 12;3(3):FSO198. doi: 10.4155/fsoa-2017-0020. eCollection 2017 Aug.

Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites.

Future science OA

Luca Galluzzi, Aurora Diotallevi, Mauro Magnani

Affiliations

  1. Department of Biomolecular Sciences, University of Urbino 'Carlo Bo', Urbino (PU), Italy.

PMID: 28883998 PMCID: PMC5583660 DOI: 10.4155/fsoa-2017-0020

Abstract

Perturbations of the physiological status of the endoplasmic reticulum (ER) trigger a specific response known as the ER stress response or unfolded protein response (UPR). In mammalian cells, the UPR is mediated by three ER transmembrane proteins (IRE1, PERK and ATF6) which activate three signaling cascades to restore ER homeostasis. In recent years, a cross-talk between UPR, inflammatory and microbial sensing pathways has been elucidated. Pathogen infection can lead to UPR activation; moreover, several pathogens subvert the UPR to promote their survival and replication. While the UPR in viral and bacterial infection has been characterized, little is known about the role of UPR in intracellular parasite infection. Here, we review recent findings on UPR induction/modulation by intracellular parasites in host cells.

Keywords: Cryptosporidium; ER stress; Leishmania; Plasmodium; Toxoplasma; immunity; protozoan parasites; unfolded protein response

Conflict of interest statement

Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with th

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